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dc.contributor.authorSalisbury, Chris
dc.contributor.authorMan, Mei-See
dc.contributor.authorBower, Peter
dc.contributor.authorGuthrie, Bruce
dc.contributor.authorChaplin, Katherine
dc.contributor.authorGaunt, Daisy M.
dc.contributor.authorBrookes, Sara
dc.contributor.authorFitzpatrick, Bridie
dc.contributor.authorGardner, Caroline
dc.contributor.authorHollinghurst, Sandra
dc.contributor.authorLee, Victoria
dc.contributor.authorMcLeod, John
dc.contributor.authorMann, Cindy
dc.contributor.authorMoffat, Keith Rafie
dc.contributor.authorMercer, Stewart W.
dc.date.accessioned2018-08-08T14:30:08Z
dc.date.available2018-08-08T14:30:08Z
dc.date.issued2018-07-07
dc.identifier253277693
dc.identifier74035222-fddc-4523-9905-ba77b1bd0063
dc.identifier85049349646
dc.identifier.citationSalisbury , C , Man , M-S , Bower , P , Guthrie , B , Chaplin , K , Gaunt , D M , Brookes , S , Fitzpatrick , B , Gardner , C , Hollinghurst , S , Lee , V , McLeod , J , Mann , C , Moffat , K R & Mercer , S W 2018 , ' Management of multimorbidity using a patient-centred care model : a pragmatic cluster-randomised trial of the 3D approach ' , Lancet , vol. 392 , no. 10141 , pp. 41-50 . https://doi.org/10.1016/S0140-6736(18)31308-4en
dc.identifier.issn0140-6736
dc.identifier.urihttps://hdl.handle.net/10023/15782
dc.descriptionFunding: National Institute for Health Researchen
dc.description.abstractBACKGROUND The management of people with multiple chronic conditions challenges health-care systems designed around single conditions. There is international consensus that care for multimorbidity should be patient-centred, focus on quality of life, and promote self-management towards agreed goals. However, there is little evidence about the effectiveness of this approach. Our hypothesis was that the patient-centred, so-called 3D approach (based on dimensions of health, depression, and drugs) for patients with multimorbidity would improve their health-related quality of life, which is the ultimate aim of the 3D intervention. METHODS We did this pragmatic cluster-randomised trial in general practices in England and Scotland. Practices were randomly allocated to continue usual care (17 practices) or to provide 6-monthly comprehensive 3D reviews, incorporating patient-centred strategies that reflected international consensus on best care (16 practices). Randomisation was computer-generated, stratified by area, and minimised by practice deprivation and list size. Adults with three or more chronic conditions were recruited. The primary outcome was quality of life (assessed with EQ-5D-5L) after 15 months' follow-up. Participants were not masked to group assignment, but analysis of outcomes was blinded. We analysed the primary outcome in the intention-to-treat population, with missing data being multiply imputed. This trial is registered as an International Standard Randomised Controlled Trial, number ISRCTN06180958. FINDINGS Between May 20, 2015, and Dec 31, 2015, we recruited 1546 patients from 33 practices and randomly assigned them to receive the intervention (n=797) or usual care (n=749). In our intention-to-treat analysis, there was no difference between trial groups in the primary outcome of quality of life (adjusted difference in mean EQ-5D-5L 0·00, 95% CI −0·02 to 0·02; p=0·93). 78 patients died, and the deaths were not considered as related to the intervention. INTERPRETATION To our knowledge, this trial is the largest investigation of the international consensus about optimal management of multimorbidity. The 3D intervention did not improve patients' quality of life.
dc.format.extent365409
dc.language.isoeng
dc.relation.ispartofLanceten
dc.subjectR Medicineen
dc.subjectE-DASen
dc.subject.lccRen
dc.titleManagement of multimorbidity using a patient-centred care model : a pragmatic cluster-randomised trial of the 3D approachen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.1016/S0140-6736(18)31308-4
dc.description.statusPeer revieweden


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