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dc.contributor.authorKrishna, Aishwarya
dc.contributor.authorHolden, Matthew T G
dc.contributor.authorPeacock, Sharon J
dc.contributor.authorEdwards, Andrew M
dc.contributor.authorWigneshweraraj, Sivaramesh
dc.date.accessioned2018-08-06T10:30:05Z
dc.date.available2018-08-06T10:30:05Z
dc.date.issued2018
dc.identifier.citationKrishna , A , Holden , M T G , Peacock , S J , Edwards , A M & Wigneshweraraj , S 2018 , ' Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility ' , Microbiology , vol. 164 , no. 9 , pp. 1189-1195 . https://doi.org/10.1099/mic.0.000695en
dc.identifier.issn1350-0872
dc.identifier.otherPURE: 255190919
dc.identifier.otherPURE UUID: 3b4b1980-2a0f-4e52-ac73-c52a1dd3acae
dc.identifier.otherPubMed: 30028663
dc.identifier.otherScopus: 85053261751
dc.identifier.otherORCID: /0000-0002-4958-2166/work/60196453
dc.identifier.otherWOS: 000453301000012
dc.identifier.urihttp://hdl.handle.net/10023/15771
dc.descriptionThis work was funded by the Imperial College President’s Scholarship awarded to A. K; M. T. G.H acknowledges funding from Chief Scientists Office (Grant Number SIRN10); S. J. P thanks the UKCRC Translational Infection Research Initiative and the Medical Research Council (Grant Number G1000803) for funding to cover the original isolate collection; A. M. E acknowledges funding from the Royal Society, Department of Medicine (Imperial College), and from the Imperial NIHR Biomedical Research Centre, Imperial College London; S.W is a recipient of a Wellcome Trust Investigator Award.en
dc.description.abstractNasal colonization by the pathogen Staphylococcus aureus is a risk factor for subsequent infection. Loss of function mutations in the gene encoding the virulence regulator Rsp are associated with the transition of S. aureus from a colonizing isolate to one that causes bacteraemia. Here, we report the identification of several novel activity-altering mutations in rsp detected in clinical isolates, including for the first time, mutations that enhance agr operon activity. We assessed how these mutations affected infection-relevant phenotypes and found loss and enhancement of function mutations to have contrasting effects on S. aureus survival in blood and antibiotic susceptibility. These findings add to the growing body of evidence that suggests S. aureus 'trades off' virulence for the acquisition of traits that benefit survival in the host, and indicates that infection severity and treatment options can be significantly affected by mutations in the virulence regulator rsp.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofMicrobiologyen
dc.rights© 2018 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectVirulence regulatoren
dc.subjectBacteraemiaen
dc.subjectStaphylococcus aureasen
dc.subjectRspen
dc.subjectMutationsen
dc.subjectQR Microbiologyen
dc.subjectNDASen
dc.subject.lccQRen
dc.titleNaturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibilityen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.Infection and Global Health Divisionen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Infection Groupen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1099/mic.0.000695
dc.description.statusPeer revieweden


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