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dc.contributor.authorSomorjai, Ildiko M. L.
dc.contributor.authorMarti-Solans, Josep
dc.contributor.authorDiaz-Gracia, Miriam
dc.contributor.authorNishida, Hiroki
dc.contributor.authorImai, Kaoru
dc.contributor.authorEscriva, Hector
dc.contributor.authorCañestro, Cristian
dc.contributor.authorAlbalat, Ricard
dc.date.accessioned2018-07-26T10:30:06Z
dc.date.available2018-07-26T10:30:06Z
dc.date.issued2018-07-25
dc.identifier.citationSomorjai , I M L , Marti-Solans , J , Diaz-Gracia , M , Nishida , H , Imai , K , Escriva , H , Cañestro , C & Albalat , R 2018 , ' Wnt evolution and function shuffling in liberal and conservative chordate genomes ' , Genome Biology , vol. 19 , 98 . https://doi.org/10.1186/s13059-018-1468-3en
dc.identifier.issn1474-760X
dc.identifier.otherPURE: 250513629
dc.identifier.otherPURE UUID: d076d71b-e383-48a1-b1f9-89f250231c19
dc.identifier.otherScopus: 85050485201
dc.identifier.otherORCID: /0000-0001-5243-6664/work/46939693
dc.identifier.otherWOS: 000439722200002
dc.identifier.urihttp://hdl.handle.net/10023/15710
dc.descriptionIS was supported by the European Union Horizon 2020 research and innovation programme under grant agreement numbers 654428 (“CORBEL”). HN was supported by Grants in Aid from The Japan Society for The Promotion of Science (22370078, 15H04377) and The Ministry of Education, Culture, Sports, Science and Thechnology, Japan (23112714, 25113518). KI was supported by a Grant in Aid from the Japan Society for the Promotion of Science (26711014). HE was supported by ANR-16-CE12-0008-01 grant from Agence Nationale de la Recherche. CC was supported by BFU2016-80601-P. RA was supported by BIO2015-67358-C2-1-P grant from Ministerio de Economía y Competitividad (Spain). CC and RA were also supported by grants BFU2010-14875 from Ministerio de Ciencia e Innovación (Spain), and SGR2014-290 and SGR2017-1665 from Generalitat de Catalunya.en
dc.description.abstractBackground: What impact gene loss has on the evolution of developmental processes, and how function shuffling has affected retained genes driving essential biological processes, remain open questions in the fields of genome evolution and EvoDevo. To investigate these problems, we have analyzed the evolution of the Wnt ligand repertoire in the chordate phylum as a case study. Results:  We conduct an exhaustive survey of Wnt genes in genomic databases, identifying 156 Wnt genes in 13 non-vertebrate chordates. This represents the most complete Wnt gene catalog of the chordate subphyla and has allowed us to resolve previous ambiguities about the orthology of many Wnt genes, including the identification of WntA for the first time in chordates. Moreover, we create the first complete expression atlas for the Wnt family during amphioxus development, providing a useful resource to investigate the evolution of Wnt expression throughout the radiation of chordates. Conclusions:  Our data underscore extraordinary genomic stasis in cephalochordates, which contrasts with the liberal and dynamic evolutionary patterns of gene loss and duplication in urochordate genomes. Our analysis has allowed us to infer ancestral Wnt functions shared among all chordates, several cases of function shuffling among Wnt paralogs, as well as unique expression domains for Wnt genes that likely reflect functional innovations in each chordate lineage. Finally, we propose a potential relationship between the evolution of WntA and the evolution of the mouth in chordates.
dc.format.extent17
dc.language.isoeng
dc.relation.ispartofGenome Biologyen
dc.rights© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectWnt evolutionen
dc.subjectGenome stasisen
dc.subjectGene lossen
dc.subjectFunction shufflingen
dc.subjectChordate WntAen
dc.subjectAscidiansen
dc.subjectVertebratesen
dc.subjectAmphioxusen
dc.subjectQH301 Biologyen
dc.subjectQR Microbiologyen
dc.subjectQH426 Geneticsen
dc.subjectDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccQH301en
dc.subject.lccQRen
dc.subject.lccQH426en
dc.titleWnt evolution and function shuffling in liberal and conservative chordate genomesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.identifier.doihttps://doi.org/10.1186/s13059-018-1468-3
dc.description.statusPeer revieweden


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