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Kinetic and NMR studies of some nitrogen heterocycles
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dc.contributor.advisor | Butler, Anthony (Anthony R.) | |
dc.contributor.author | Anderson, Lesley Marion | |
dc.coverage.spatial | 100 p. | en_US |
dc.date.accessioned | 2018-07-12T10:07:30Z | |
dc.date.available | 2018-07-12T10:07:30Z | |
dc.date.issued | 1990 | |
dc.identifier.uri | https://hdl.handle.net/10023/15295 | |
dc.description.abstract | The work carried out in this thesis involves the investigation of some reactions of heterocyclic compounds by a wide range of spectroscopic and kinetic techniques. Chapter 1 describes several methods, including stopped-flow spectrophotometry, high pressure kinetics and MNDO calculations, which are used to analyse the mechanism of the reaction of imidazole with diazonium ions. Chapter 2 describes the use of the temperature-jump technique to follow the extremely fast protonation of pyrroles. Diazonium ions are further investigated in Chapter 3 which examines the structure of p-nitrobenzenediazonium tetrafluoroborate by X-ray crystallography. The nature of other benzenediazonium ions and some of their complexes is also investigated by solid state ¹⁵N nmr spectroscopy. Chapter 4 switches the emphasis to nmr spectroscopy. The reactive intermediates of reactions of benzil with nitrogen heterocycles are investigated using ¹³c nmr spectroscopy in a kinetic application. Chapters 5 and 6 continue the use of nmr spectroscopy in the structural assignment of bilirubin and the determination of the nature of bilirubin inclusion complexes. Chapter 6 also examines by spectrophotometry the reaction used in the clinical analysis of bilirubin and the effect on this reaction of binding agents such as albumin and α-cyclodextrin. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of St Andrews | |
dc.subject.lcc | QD401.A6 | |
dc.subject.lcc | Heterocyclic compounds | en |
dc.title | Kinetic and NMR studies of some nitrogen heterocycles | en_US |
dc.type | Thesis | en_US |
dc.contributor.sponsor | Rollo Trust | en_US |
dc.type.qualificationlevel | Doctoral | en_US |
dc.type.qualificationname | PhD Doctor of Philosophy | en_US |
dc.publisher.institution | The University of St Andrews | en_US |
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