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dc.contributor.authorLe Gallou, Simon
dc.contributor.authorZhou, Zhicheng
dc.contributor.authorThai, Lan-Huong
dc.contributor.authorFritzen, Remi
dc.contributor.authorde Los Aires, Alba Verge
dc.contributor.authorMégret, Jérôme
dc.contributor.authorYu, Philipp
dc.contributor.authorKitamura, Daisuke
dc.contributor.authorBille, Emmanuelle
dc.contributor.authorTros, Fabiola
dc.contributor.authorNassif, Xavier
dc.contributor.authorCharbit, Alain
dc.contributor.authorWeller, Sandra
dc.contributor.authorWeill, Jean-Claude
dc.contributor.authorReynaud, Claude-Agnès
dc.date.accessioned2018-07-10T10:30:05Z
dc.date.available2018-07-10T10:30:05Z
dc.date.issued2018-08
dc.identifier.citationLe Gallou , S , Zhou , Z , Thai , L-H , Fritzen , R , de Los Aires , A V , Mégret , J , Yu , P , Kitamura , D , Bille , E , Tros , F , Nassif , X , Charbit , A , Weller , S , Weill , J-C & Reynaud , C-A 2018 , ' A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses ' , Journal of Experimental Medicine , vol. 215 , no. 8 , pp. 2035-2053 . https://doi.org/10.1084/jem.20180977en
dc.identifier.issn0022-1007
dc.identifier.otherPURE: 254446180
dc.identifier.otherPURE UUID: 842f1d66-d189-4c4c-ba39-a8cf81475d1a
dc.identifier.otherPubMed: 29959173
dc.identifier.otherScopus: 85054765546
dc.identifier.otherORCID: /0000-0003-3457-8364/work/46569365
dc.identifier.otherWOS: 000440828500008
dc.identifier.urihttp://hdl.handle.net/10023/15169
dc.descriptionThis work was supported by the Ligue contre le Cancer (“Equipe labellisée”), the Fondation Princesse Grace de Monaco, and the European Research Council Advanced grants “Memo-B” (to J.-C. Weill) and “B-response” (to C.-A. Reynaud). L.-H. Thai was supported by a Poste d'Accueil INS ERM.en
dc.description.abstractTo what extent immune responses against the gut flora are compartmentalized within mucosal tissues in homeostatic conditions remains a much-debated issue. We describe here, based on an inducible AID fate-mapping mouse model, that systemic memory B cell subsets, including mainly IgM+ B cells in spleen, together with IgA+ plasma cells in spleen and bone marrow, are generated in mice in the absence of deliberate immunization. While the IgA component appears dependent on the gut flora, IgM memory B cells are still generated in germ-free mice, albeit to a reduced extent. Clonal relationships and renewal kinetics after anti-CD20 treatment reveal that this long-lasting splenic population is mainly sustained by output of B cell clones persisting in mucosal germinal centers. IgM-secreting hybridomas established from splenic IgM memory B cells showed reactivity against various bacterial isolates and endogenous retroviruses. Ongoing activation of B cells in gut-associated lymphoid tissues thus generates a diversified systemic compartment showing long-lasting clonal persistence and protective capacity against systemic bacterial infections.
dc.format.extent19
dc.language.isoeng
dc.relation.ispartofJournal of Experimental Medicineen
dc.rights© 2018 Le Gallou et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4 .0/).en
dc.subjectQR180 Immunologyen
dc.subjectNDASen
dc.subject.lccQR180en
dc.titleA splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responsesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.identifier.doihttps://doi.org/10.1084/jem.20180977
dc.description.statusPeer revieweden


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