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dc.contributor.authorAlfaida, Mabruka
dc.contributor.authorChamberlain, Janet
dc.contributor.authorRothman, Alexander
dc.contributor.authorCrossman, David Christopher
dc.contributor.authorVilla-Uriol, Maria-Cruz
dc.contributor.authorHadoke, Partick
dc.contributor.authorWu, Junxi
dc.contributor.authorSchenkel, Torsten
dc.contributor.authorEvans, Paul
dc.contributor.authorFrancis, Sheila
dc.date.accessioned2018-07-05T13:30:05Z
dc.date.available2018-07-05T13:30:05Z
dc.date.issued2018-07-03
dc.identifier.citationAlfaida , M , Chamberlain , J , Rothman , A , Crossman , D C , Villa-Uriol , M-C , Hadoke , P , Wu , J , Schenkel , T , Evans , P & Francis , S 2018 , ' Dietary docosahexaenoic acid reduces oscillatory wall shear stress, atherosclerosis and hypertension, most likely mediated via an IL-1-mediated mechanism ' , Journal of the American Heart Association , vol. 7 , no. 13 , e008757 . https://doi.org/10.1161/JAHA.118.008757en
dc.identifier.issn2047-9980
dc.identifier.otherPURE: 253247795
dc.identifier.otherPURE UUID: 97cf29c6-1c3a-4a0c-a208-da8915ecc548
dc.identifier.otherScopus: 85049679169
dc.identifier.otherORCID: /0000-0003-4762-8623/work/60196620
dc.identifier.otherWOS: 000452700100023
dc.identifier.urihttp://hdl.handle.net/10023/14997
dc.description.abstractBackground Hypertension is a complex condition and a common cardiovascular risk factor. Dietary docosahexaenoic acid (DHA) modulates atherosclerosis and hypertension, possibly via an inflammatory mechanism. IL‐1 (interleukin 1) has an established role in atherosclerosis and inflammation, although whether IL‐1 inhibition modulates blood pressure is unclear. Methods and Results Male apoE−/− (apolipoprotein E–null) mice were fed either a high fat diet or a high fat diet plus DHA (300 mg/kg per day) for 12 weeks. Blood pressure and cardiac function were assessed, and effects of DHA on wall shear stress and atherosclerosis were determined. DHA supplementation improved left ventricular function, reduced wall shear stress and oscillatory shear at ostia in the descending aorta, and significantly lowered blood pressure compared with controls (119.5±7 versus 159.7±3 mm Hg, P<0.001, n=4 per group). Analysis of atheroma following DHA feeding in mice demonstrated a 4‐fold reduction in lesion burden in distal aortas and in brachiocephalic arteries (P<0.001, n=12 per group). In addition, DHA treatment selectively decreased plaque endothelial IL‐1β (P<0.01). Conclusions Our findings revealed that raised blood pressure can be reduced by inhibiting IL‐1 indirectly by administration of DHA in the diet through a mechanism that involves a reduction in wall shear stress and local expression of the proinflammatory cytokine IL‐1β.
dc.format.extent19
dc.language.isoeng
dc.relation.ispartofJournal of the American Heart Associationen
dc.rights© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectDocosahexaenoic aciden
dc.subjectEndotheliumen
dc.subjectHypertensionen
dc.subjectInflammationen
dc.subjectInterleukin 1en
dc.subjectWall shear stressen
dc.subjectRB Pathologyen
dc.subjectNDASen
dc.subject.lccRBen
dc.titleDietary docosahexaenoic acid reduces oscillatory wall shear stress, atherosclerosis and hypertension, most likely mediated via an IL-1-mediated mechanismen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Office of the Principalen
dc.identifier.doihttps://doi.org/10.1161/JAHA.118.008757
dc.description.statusPeer revieweden


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