Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorJammeh, Emmanuel A.
dc.contributor.authorCarroll, Camille B.
dc.contributor.authorPearson, Stephen W.
dc.contributor.authorEscudero, Javier
dc.contributor.authorAnastasiou, Athanasios
dc.contributor.authorZhao, Peng
dc.contributor.authorChenore, Todd
dc.contributor.authorZajicek, John
dc.contributor.authorIfeachor, Emmanuel
dc.date.accessioned2018-06-27T08:30:06Z
dc.date.available2018-06-27T08:30:06Z
dc.date.issued2018-06-12
dc.identifier.citationJammeh , E A , Carroll , C B , Pearson , S W , Escudero , J , Anastasiou , A , Zhao , P , Chenore , T , Zajicek , J & Ifeachor , E 2018 , ' Machine-learning based identification of undiagnosed dementia in primary care : a feasibility study ' , BJGP Open , vol. 2 , no. 2 , bjgpopen18X101589 . https://doi.org/10.3399/bjgpopen18X101589en
dc.identifier.issn2398-3795
dc.identifier.otherPURE: 253425361
dc.identifier.otherPURE UUID: ad8c9710-f20f-42b4-ad99-9c5ab0668733
dc.identifier.otherORCID: /0000-0003-3481-825X/work/64034669
dc.identifier.otherScopus: 85074425970
dc.identifier.urihttp://hdl.handle.net/10023/14651
dc.descriptionThis article presents independent research commissioned by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (grant reference number: RP-PG-0707-10124). Financial support from the UK Engineering and Physical Sciences Research Council (EPSRC) (grant reference number: EP/M006301/1) and the EU Horizon 2020 (EU H2020) Marie Skłodowska-Curie Innovative Training Networks (grant reference number: 721281) is also gratefully acknowledged.en
dc.description.abstractBackground : Up to half of patients with dementia may not receive a formal diagnosis, limiting access to appropriate services. It is hypothesised that it may be possible to identify undiagnosed dementia from a profile of symptoms recorded in routine clinical practice. Aim :  The aim of this study is to develop a machine learning-based model that could be used in general practice to detect dementia from routinely collected NHS data. The model would be a useful tool for identifying people who may be living with dementia but have not been formally diagnosed. Design & setting : The study involved a case-control design and analysis of primary care data routinely collected over a 2-year period. Dementia diagnosed during the study period was compared to no diagnosis of dementia during the same period using pseudonymised routinely collected primary care clinical data. Method : Routinely collected Read-encoded data were obtained from 18 consenting GP surgeries across Devon, for 26 483 patients aged >65 years. The authors determined Read codes assigned to patients that may contribute to dementia risk. These codes were used as features to train a machine-learning classification model to identify patients that may have underlying dementia. Results: The model obtained sensitivity and specificity values of 84.47% and 86.67%, respectively. Conclusion:  The results show that routinely collected primary care data may be used to identify undiagnosed dementia. The methodology is promising and, if successfully developed and deployed, may help to increase dementia diagnosis in primary care.
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofBJGP Openen
dc.rightsCopyright (c) 2018 the authors. This article is published under a Creative Commons licence (https://creativecommons.org/licenses/by/4.0/) that allows reuse subject only to the article being fully attributed. The article is published at https://doi.org/10.3399/bjgpopen18X101589en
dc.subjectNHS dataen
dc.subjectPrimary careen
dc.subjectGP practiceen
dc.subjectMachine learningen
dc.subjectRead codeen
dc.subjectDementiaen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectE-NDASen
dc.subject.lccRC0321en
dc.titleMachine-learning based identification of undiagnosed dementia in primary care : a feasibility studyen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Cellular Medicine Divisionen
dc.identifier.doihttps://doi.org/10.3399/bjgpopen18X101589
dc.description.statusPeer revieweden


This item appears in the following Collection(s)

Show simple item record