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dc.contributor.authorAdamson, Catherine S
dc.contributor.authorSakalian, M
dc.contributor.authorSalzwedel, K
dc.contributor.authorFreed, E.O.
dc.date.accessioned2010-11-23T10:23:14Z
dc.date.available2010-11-23T10:23:15Z
dc.date.issued2010-04
dc.identifier.citationAdamson , C S , Sakalian , M , Salzwedel , K & Freed , E O 2010 , ' Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat ' , Retrovirology , vol. 7 , 36 . https://doi.org/10.1186/1742-4690-7-36en
dc.identifier.issn1742-4690
dc.identifier.otherPURE: 482525
dc.identifier.otherPURE UUID: 55a5d03d-b17f-4d93-b8ef-50de95fe640a
dc.identifier.otherstandrews_research_output: 32688
dc.identifier.otherScopus: 77950929797
dc.identifier.otherWOS: 000278330800001
dc.identifier.otherORCID: /0000-0001-7673-5212/work/60630450
dc.identifier.urihttp://hdl.handle.net/10023/1439
dc.description.abstractBackground: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-1-infected patients do not respond to BVM. A patient’s failure to respond correlated with baseline polymorphisms at SP1 residues 6-8. Results: In this study, we demonstrate that varying levels of BVM resistance are associated with point mutations at these residues. BVM susceptibility was maintained by SP1-Q6A, -Q6H and -T8A mutations. However, an SP1-V7A mutation conferred high-level BVM resistance and SP1-V7M and T8Δ mutations conferred intermediate levels of BVM resistance. Conclusions: Future exploitation of the CA-SP1 cleavage site as an antiretroviral drug target will need to overcome the baseline variability in the SP1 region of Gag.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofRetrovirologyen
dc.rights© 2010 Adamson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectQR355 Virologyen
dc.subject.lccQR355en
dc.titlePolymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimaten
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1186/1742-4690-7-36
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=77950929797&partnerID=8YFLogxKen


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