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dc.contributor.authorAdamson, Catherine S
dc.contributor.authorSakalian, M
dc.contributor.authorSalzwedel, K
dc.contributor.authorFreed, E.O.
dc.identifier.citationAdamson , C S , Sakalian , M , Salzwedel , K & Freed , E O 2010 , ' Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat ' , Retrovirology , vol. 7 , 36 .
dc.identifier.otherPURE: 482525
dc.identifier.otherPURE UUID: 55a5d03d-b17f-4d93-b8ef-50de95fe640a
dc.identifier.otherstandrews_research_output: 32688
dc.identifier.otherScopus: 77950929797
dc.identifier.otherWOS: 000278330800001
dc.identifier.otherORCID: /0000-0001-7673-5212/work/60630450
dc.description.abstractBackground: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-1-infected patients do not respond to BVM. A patient’s failure to respond correlated with baseline polymorphisms at SP1 residues 6-8. Results: In this study, we demonstrate that varying levels of BVM resistance are associated with point mutations at these residues. BVM susceptibility was maintained by SP1-Q6A, -Q6H and -T8A mutations. However, an SP1-V7A mutation conferred high-level BVM resistance and SP1-V7M and T8Δ mutations conferred intermediate levels of BVM resistance. Conclusions: Future exploitation of the CA-SP1 cleavage site as an antiretroviral drug target will need to overcome the baseline variability in the SP1 region of Gag.
dc.rights© 2010 Adamson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectQR355 Virologyen
dc.titlePolymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimaten
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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