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dc.contributor.authorBarton-Owen, Thomas
dc.contributor.authorFerrier, David E. K.
dc.contributor.authorSomorjai, Ildikó M. L.
dc.date.accessioned2018-06-20T11:30:06Z
dc.date.available2018-06-20T11:30:06Z
dc.date.issued2018-06-20
dc.identifier.citationBarton-Owen , T , Ferrier , D E K & Somorjai , I M L 2018 , ' Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage ' , Scientific Reports , vol. 8 , 9414 . https://doi.org/10.1038/s41598-018-27700-xen
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 250513684
dc.identifier.otherPURE UUID: ec8497e0-39a6-4afc-b309-2ee5b651ca82
dc.identifier.otherScopus: 85048892092
dc.identifier.otherORCID: /0000-0003-3247-6233/work/45947559
dc.identifier.otherORCID: /0000-0001-5243-6664/work/46168676
dc.identifier.otherWOS: 000435630400019
dc.identifier.urihttps://hdl.handle.net/10023/14330
dc.descriptionFunding for this research was provided by the European Union’s Horizon 2020 research and innovation programme under grant agreement number 654428 (“CORBEL”) and a MASTS (Marine Alliance for Science and Technology Scotland) PECRE young investigator award to IMLS. This work was supported by the Branchiostoma lanceolatum genome consortium, which provided access to the Branchiostoma lanceolatum genome sequence.en
dc.description.abstractThe Pax3/7 transcription factor family is integral to developmental gene networks contributing to important innovations in vertebrate evolution, including the neural crest. The basal chordate lineage of amphioxus is ideally placed to understand the dynamics of the gene regulatory network evolution that produced these novelties. We report here the discovery that the cephalochordate lineage possesses two Pax3/7 genes, Pax3/7a and Pax3/7b. The tandem duplication is ancestral to all extant amphioxus, occurring in both Asymmetron and Branchiostoma, but originated after the split from the lineage leading to vertebrates. The two paralogues are differentially expressed during embryonic development, particularly in neural and somitic tissues, suggesting distinct regulation. Our results have implications for the study of amphioxus regeneration, neural plate and crest evolution, and differential tandem paralogue evolution.
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofScientific Reportsen
dc.rights© The Author(s) 2018. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectQH301 Biologyen
dc.subjectNDASen
dc.subjectBDCen
dc.subject.lccQH301en
dc.titlePax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineageen
dc.typeJournal articleen
dc.contributor.sponsorEuropean Commissionen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1038/s41598-018-27700-x
dc.description.statusPeer revieweden
dc.identifier.grantnumber654248en


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