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The meaning of intragenomic conflict
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dc.contributor.author | Gardner, Andy | |
dc.contributor.author | Úbeda, Francisco | |
dc.date.accessioned | 2018-05-06T23:33:41Z | |
dc.date.available | 2018-05-06T23:33:41Z | |
dc.date.issued | 2017-12 | |
dc.identifier | 251138747 | |
dc.identifier | 6c6f8ab6-68e5-4531-bec7-dc4823982940 | |
dc.identifier | 85033384749 | |
dc.identifier | 000417194600007 | |
dc.identifier.citation | Gardner , A & Úbeda , F 2017 , ' The meaning of intragenomic conflict ' , Nature Ecology and Evolution , vol. 1 , no. 12 , pp. 1807-1815 . https://doi.org/10.1038/s41559-017-0354-9 | en |
dc.identifier.issn | 2397-334X | |
dc.identifier.uri | https://hdl.handle.net/10023/13307 | |
dc.description | Funding: Independent Research Fellowship from the Natural Environment Research Council (NE/K009524/1) (AG). | en |
dc.description.abstract | Recent years have seen an explosion of interest in genes that function for their own good and to the detriment of other genes that reside in the same genome. Such intragenomic conflicts are increasingly recognized to underpin maladaptation and disease. However, progress has been impeded by a lack of clear understanding regarding what intragenomic conflict actually means, and an associated obscurity concerning its fundamental drivers. Here we develop a general theory of intragenomic conflict in which genes are viewed as inclusive-fitness-maximizing agents that come into conflict when their inclusive-fitness interests disagree. This yields a classification of all intragenomic conflicts into three categories according to whether genes disagree about where they have come from, where they are going, or where they currently are. We illustrate each of these three basic categories, survey and classify all known forms of intragenomic conflict, and discuss the implications for organismal maladaptation and human disease. | |
dc.format.extent | 1154296 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Ecology and Evolution | en |
dc.subject | QH426 Genetics | en |
dc.subject | T-NDAS | en |
dc.subject | BDC | en |
dc.subject | R2C | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QH426 | en |
dc.title | The meaning of intragenomic conflict | en |
dc.type | Journal article | en |
dc.contributor.sponsor | NERC | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Centre for Biological Diversity | en |
dc.identifier.doi | 10.1038/s41559-017-0354-9 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-05-06 | |
dc.identifier.grantnumber | NE/K009524/1 | en |
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