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dc.contributor.authorKeller, Simon S.
dc.contributor.authorRoberts, Neil
dc.contributor.authorBaker, Gus
dc.contributor.authorSluming, Vanessa
dc.contributor.authorCezayirli, Enis
dc.contributor.authorMayes, Andrews
dc.contributor.authorEldridge, Paul
dc.contributor.authorMarson, Anthony
dc.contributor.authorWieshmann, Udo
dc.identifier.citationKeller , S S , Roberts , N , Baker , G , Sluming , V , Cezayirli , E , Mayes , A , Eldridge , P , Marson , A & Wieshmann , U 2018 , ' A voxel-based asymmetry study of the relationship between hemispheric asymmetry and language dominance in Wada tested patients ' , Human Brain Mapping , vol. Early View .
dc.identifier.otherPURE: 252899588
dc.identifier.otherPURE UUID: 03346f02-a63e-409f-a1fe-f646e634ac9b
dc.identifier.otherScopus: 85044307896
dc.identifier.otherWOS: 000437682100026
dc.descriptionSSK was supported by a UK Medical Research Council grant (grant number MR/K023152/1).en
dc.description.abstractDetermining the anatomical basis of hemispheric language dominance (HLD) remains an important scientific endeavor. The Wada test remains the gold standard test for HLD and provides a unique opportunity to determine the relationship between HLD and hemispheric structural asymmetries on MRI. In this study, we applied a whole‐brain voxel‐based asymmetry (VBA) approach to determine the relationship between interhemispheric structural asymmetries and HLD in a large consecutive sample of Wada tested patients. Of 135 patients, 114 (84.4%) had left HLD, 10 (7.4%) right HLD, and 11 (8.2%) bilateral language representation. Fifty‐four controls were also studied. Right‐handed controls and right‐handed patients with left HLD had comparable structural brain asymmetries in cortical, subcortical, and cerebellar regions that have previously been documented in healthy people. However, these patients and controls differed in structural asymmetry of the mesial temporal lobe and a circumscribed region in the superior temporal gyrus, suggesting that only asymmetries of these regions were due to brain alterations caused by epilepsy. Additional comparisons between patients with left and right HLD, matched for type and location of epilepsy, revealed that structural asymmetries of insula, pars triangularis, inferior temporal gyrus, orbitofrontal cortex, ventral temporo‐occipital cortex, mesial somatosensory cortex, and mesial cerebellum were significantly associated with the side of HLD. Patients with right HLD and bilateral language representation were significantly less right‐handed. These results suggest that structural asymmetries of an insular‐fronto‐temporal network may be related to HLD.
dc.relation.ispartofHuman Brain Mappingen
dc.rights© 2018 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectBroca's areaen
dc.subjectCerebral asymmetryen
dc.subjectLanguage lateralizationen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectBF Psychologyen
dc.titleA voxel-based asymmetry study of the relationship between hemispheric asymmetry and language dominance in Wada tested patientsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Education Divisionen
dc.description.statusPeer revieweden

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