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dc.contributor.authorHao, Li
dc.contributor.authorHolden, Matthew T. G.
dc.contributor.authorWang, Xin
dc.contributor.authorAndrew, Lubomira
dc.contributor.authorWellnitz, Sabine
dc.contributor.authorHu, Fang
dc.contributor.authorWhaley, Melissa
dc.contributor.authorSammons, Scott
dc.contributor.authorKnipe, Kristen
dc.contributor.authorFrace, Mike
dc.contributor.authorMcNamara, Lucy A
dc.contributor.authorLiberator, Paul
dc.contributor.authorAnderson, Annaliesa S
dc.date.accessioned2018-04-18T08:30:13Z
dc.date.available2018-04-18T08:30:13Z
dc.date.issued2018-04
dc.identifier.citationHao , L , Holden , M T G , Wang , X , Andrew , L , Wellnitz , S , Hu , F , Whaley , M , Sammons , S , Knipe , K , Frace , M , McNamara , L A , Liberator , P & Anderson , A S 2018 , ' Distinct evolutionary patterns of Neisseria meningitidis serogroup B disease outbreaks at two universities in the USA ' , Microbial Genomics , vol. 4 , no. 4 , e000155 . https://doi.org/10.1099/mgen.0.000155en
dc.identifier.issn2057-5858
dc.identifier.otherPURE: 252839418
dc.identifier.otherPURE UUID: 1ef1abf1-374e-4496-879d-39521cb73462
dc.identifier.otherPubMed: 29616896
dc.identifier.otherScopus: 85058468823
dc.identifier.otherORCID: /0000-0002-4958-2166/work/60196419
dc.identifier.otherWOS: 000431156200001
dc.identifier.urihttps://hdl.handle.net/10023/13154
dc.descriptionL. H., L. A., S. W., P. L. and A. S. A. are current employees of Pfizer, and this work was funded by Pfizer Inc.en
dc.description.abstractNeisseria meningitidis serogroup B (MnB) was responsible for two independent meningococcal disease outbreaks at universities in the USA during 2013. The first at University A in New Jersey included nine confirmed cases reported between March 2013 and March 2014. The second outbreak occurred at University B in California, with four confirmed cases during November 2013. The public health response to these outbreaks included the approval and deployment of a serogroup B meningococcal vaccine that was not yet licensed in the USA. This study investigated the use of whole-genome sequencing(WGS) to examine the genetic profile of the disease-causing outbreak isolates at each university. Comparative WGS revealed differences in evolutionary patterns between the two disease outbreaks. The University A outbreak isolates were very closely related, with differences primarily attributed to single nucleotide polymorphisms/insertion-deletion (SNP/indel) events. In contrast, the University B outbreak isolates segregated into two phylogenetic clades, differing in large part due to recombination events covering extensive regions (>30 kb) of the genome including virulence factors. This high-resolution comparison of two meningococcal disease outbreaks further demonstrates the genetic complexity of meningococcal bacteria as related to evolution and disease virulence.
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofMicrobial Genomicsen
dc.rights© 2018 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.en
dc.subjectSerogroup B Neisseria meningitidisen
dc.subjectDisease outbreaken
dc.subjectMulti-locus sequence typing (MLST)en
dc.subjectWhole genome sequence (WGS)en
dc.subjectSingle nucleotide polymorphism (SNP)en
dc.subjectVaccineen
dc.subjectQR355 Virologyen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQR355en
dc.subject.lccRA0421en
dc.titleDistinct evolutionary patterns of Neisseria meningitidis serogroup B disease outbreaks at two universities in the USAen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.contributor.institutionUniversity of St Andrews. Infection Groupen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1099/mgen.0.000155
dc.description.statusPeer revieweden


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