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dc.contributor.authorDomschke, Pia
dc.contributor.authorTrucu, Dumitru
dc.contributor.authorGerisch, Alf
dc.contributor.authorChaplain, Mark Andrew Joseph
dc.date.accessioned2018-04-12T23:33:30Z
dc.date.available2018-04-12T23:33:30Z
dc.date.issued2017-12
dc.identifier.citationDomschke , P , Trucu , D , Gerisch , A & Chaplain , M A J 2017 , ' Structured models of cell migration incorporating molecular binding processes ' , Journal of Mathematical Biology , vol. 75 , no. 6-7 , pp. 1517-1561 . https://doi.org/10.1007/s00285-017-1120-yen
dc.identifier.issn0303-6812
dc.identifier.otherPURE: 249576825
dc.identifier.otherPURE UUID: 3cc2713e-481f-4174-982e-93747c899f46
dc.identifier.otherScopus: 84995539364
dc.identifier.otherORCID: /0000-0001-5727-2160/work/55378939
dc.identifier.otherWOS: 000413032600007
dc.identifier.urihttp://hdl.handle.net/10023/13127
dc.descriptionDT and MAJC gratefully acknowledge the support of the ERC Advanced Investigator Grant 227619, “M5CGS - From Mutations to Metastases: Multiscale Mathematical Modelling of Cancer Growth and Spread”.en
dc.description.abstractThe dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with three examples arising from cancer invasion.
dc.format.extent45
dc.language.isoeng
dc.relation.ispartofJournal of Mathematical Biologyen
dc.rights© 2017, Springer-Verlag Berlin Heidelberg. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1007/s00285-017-1120-yen
dc.subjectStructured population modellingen
dc.subjectSpatio-temporal modelen
dc.subjectCell-surface receptorsen
dc.subjectCancer invasionen
dc.subjectQA Mathematicsen
dc.subjectQH301 Biologyen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectNDASen
dc.subjectBDCen
dc.subject.lccQAen
dc.subject.lccQH301en
dc.subject.lccRC0254en
dc.titleStructured models of cell migration incorporating molecular binding processesen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.Applied Mathematicsen
dc.identifier.doihttps://doi.org/10.1007/s00285-017-1120-y
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-04-12


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