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dc.contributor.authorDomschke, Pia
dc.contributor.authorTrucu, Dumitru
dc.contributor.authorGerisch, Alf
dc.contributor.authorChaplain, Mark Andrew Joseph
dc.date.accessioned2018-04-12T23:33:30Z
dc.date.available2018-04-12T23:33:30Z
dc.date.issued2017-12
dc.identifier249576825
dc.identifier3cc2713e-481f-4174-982e-93747c899f46
dc.identifier84995539364
dc.identifier000413032600007
dc.identifier.citationDomschke , P , Trucu , D , Gerisch , A & Chaplain , M A J 2017 , ' Structured models of cell migration incorporating molecular binding processes ' , Journal of Mathematical Biology , vol. 75 , no. 6-7 , pp. 1517-1561 . https://doi.org/10.1007/s00285-017-1120-yen
dc.identifier.issn0303-6812
dc.identifier.otherORCID: /0000-0001-5727-2160/work/55378939
dc.identifier.urihttps://hdl.handle.net/10023/13127
dc.descriptionDT and MAJC gratefully acknowledge the support of the ERC Advanced Investigator Grant 227619, “M5CGS - From Mutations to Metastases: Multiscale Mathematical Modelling of Cancer Growth and Spread”.en
dc.description.abstractThe dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with three examples arising from cancer invasion.
dc.format.extent45
dc.format.extent925626
dc.language.isoeng
dc.relation.ispartofJournal of Mathematical Biologyen
dc.subjectStructured population modellingen
dc.subjectSpatio-temporal modelen
dc.subjectCell-surface receptorsen
dc.subjectCancer invasionen
dc.subjectQA Mathematicsen
dc.subjectQH301 Biologyen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectNDASen
dc.subjectBDCen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQAen
dc.subject.lccQH301en
dc.subject.lccRC0254en
dc.titleStructured models of cell migration incorporating molecular binding processesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. Applied Mathematicsen
dc.identifier.doi10.1007/s00285-017-1120-y
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-04-12


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