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Structured models of cell migration incorporating molecular binding processes
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dc.contributor.author | Domschke, Pia | |
dc.contributor.author | Trucu, Dumitru | |
dc.contributor.author | Gerisch, Alf | |
dc.contributor.author | Chaplain, Mark Andrew Joseph | |
dc.date.accessioned | 2018-04-12T23:33:30Z | |
dc.date.available | 2018-04-12T23:33:30Z | |
dc.date.issued | 2017-12 | |
dc.identifier | 249576825 | |
dc.identifier | 3cc2713e-481f-4174-982e-93747c899f46 | |
dc.identifier | 84995539364 | |
dc.identifier | 000413032600007 | |
dc.identifier.citation | Domschke , P , Trucu , D , Gerisch , A & Chaplain , M A J 2017 , ' Structured models of cell migration incorporating molecular binding processes ' , Journal of Mathematical Biology , vol. 75 , no. 6-7 , pp. 1517-1561 . https://doi.org/10.1007/s00285-017-1120-y | en |
dc.identifier.issn | 0303-6812 | |
dc.identifier.other | ORCID: /0000-0001-5727-2160/work/55378939 | |
dc.identifier.uri | https://hdl.handle.net/10023/13127 | |
dc.description | DT and MAJC gratefully acknowledge the support of the ERC Advanced Investigator Grant 227619, “M5CGS - From Mutations to Metastases: Multiscale Mathematical Modelling of Cancer Growth and Spread”. | en |
dc.description.abstract | The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with three examples arising from cancer invasion. | |
dc.format.extent | 45 | |
dc.format.extent | 925626 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Mathematical Biology | en |
dc.subject | Structured population modelling | en |
dc.subject | Spatio-temporal model | en |
dc.subject | Cell-surface receptors | en |
dc.subject | Cancer invasion | en |
dc.subject | QA Mathematics | en |
dc.subject | QH301 Biology | en |
dc.subject | RC0254 Neoplasms. Tumors. Oncology (including Cancer) | en |
dc.subject | NDAS | en |
dc.subject | BDC | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QA | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | RC0254 | en |
dc.title | Structured models of cell migration incorporating molecular binding processes | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. Applied Mathematics | en |
dc.identifier.doi | 10.1007/s00285-017-1120-y | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-04-12 |
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