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Cryptococcal meningitis : epidemiology and therapeutic options
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dc.contributor.author | Sloan, Derek J. | |
dc.contributor.author | Parris, Victoria | |
dc.date.accessioned | 2018-03-27T14:30:04Z | |
dc.date.available | 2018-03-27T14:30:04Z | |
dc.date.issued | 2014-05-13 | |
dc.identifier | 241921155 | |
dc.identifier | 9f3b2fe0-9c0a-4af1-a573-283746c2f3b1 | |
dc.identifier | 84900559961 | |
dc.identifier.citation | Sloan , D J & Parris , V 2014 , ' Cryptococcal meningitis : epidemiology and therapeutic options ' , Journal of Clinical Epidemiology , vol. 6 , pp. 169-182 . https://doi.org/10.2147/CLEP.S38850 | en |
dc.identifier.issn | 0895-4356 | |
dc.identifier.uri | https://hdl.handle.net/10023/13031 | |
dc.description.abstract | Cryptococcal meningitis causes morbidity and mortality worldwide. The burden of disease is greatest in middle- and low-income countries with a high incidence of human immunodeficiency virus (HIV infection. Patients taking immunosuppressive drugs and some immunocompetent hosts are also at risk. Treatment of cryptococcal meningitis consists of three phases: Induction, consolidation, and maintenance. Effective induction therapy requires potent fungicidal drugs (amphotericin B and flucytosine, which are often unavailable in low-resource, high-endemicity settings. As a consequence, mortality is unacceptably high. Wider access to effective treatment is urgently required to improve outcomes. For human immunodeficiency virus-infected patients, judicious management of asymptomatic cryptococcal antigenemia and appropriately timed introduction of antiretroviral therapy are important. | |
dc.format.extent | 14 | |
dc.format.extent | 691890 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Clinical Epidemiology | en |
dc.subject | Antifungal therapy | en |
dc.subject | Antiretroviral therapy | en |
dc.subject | Cryptococcosis | en |
dc.subject | HIV | en |
dc.subject | Immune reconstitution inflammatory syndrome | en |
dc.subject | Immunosuppression | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | Epidemiology | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RA0421 | en |
dc.subject.lcc | RM | en |
dc.title | Cryptococcal meningitis : epidemiology and therapeutic options | en |
dc.type | Journal item | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.identifier.doi | https://doi.org/10.2147/CLEP.S38850 | |
dc.description.status | Peer reviewed | en |
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