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dc.contributor.authorAbbara, A.
dc.contributor.authorIslam, R.
dc.contributor.authorClarke, S. A.
dc.contributor.authorJeffers, L.
dc.contributor.authorChristopoulos, G.
dc.contributor.authorComninos, A. N.
dc.contributor.authorSalim, R.
dc.contributor.authorLavery, S. A.
dc.contributor.authorVuong, T.N.L.
dc.contributor.authorHumaidan, P.
dc.contributor.authorKelsey, T. W.
dc.contributor.authorTrew, G.H.
dc.contributor.authorDhillo, W.S.
dc.date.accessioned2018-03-06T12:30:07Z
dc.date.available2018-03-06T12:30:07Z
dc.date.issued2018-06
dc.identifier.citationAbbara , A , Islam , R , Clarke , S A , Jeffers , L , Christopoulos , G , Comninos , A N , Salim , R , Lavery , S A , Vuong , T N L , Humaidan , P , Kelsey , T W , Trew , G H & Dhillo , W S 2018 , ' Clinical parameters of ovarian hyperstimulation syndrome (OHSS) following different triggers of oocyte maturation in IVF treatment ' , Clinical Endocrinology , vol. 88 , no. 6 , pp. 920-927 . https://doi.org/10.1111/cen.13569en
dc.identifier.issn0300-0664
dc.identifier.otherPURE: 252288483
dc.identifier.otherPURE UUID: e4d671cb-9255-4415-bd80-9deee53a576f
dc.identifier.otherScopus: 85043321414
dc.identifier.otherORCID: /0000-0002-8091-1458/work/42504521
dc.identifier.otherWOS: 000434078900020
dc.identifier.urihttp://hdl.handle.net/10023/12859
dc.descriptionThis paper presents independent research funded by grants from the MRC, BBSRC and NIHR and supported by the NIHR Clinical Research Facility and Biomedical Research Centre at Imperial College Healthcare NHS Trust.en
dc.description.abstractObjective. Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic condition, predominantly related to the hormone used to induce oocyte maturation during IVF treatment. Kisspeptin is a hypothalamic neuropeptide that has recently been demonstrated to safely trigger final oocyte maturation during IVF treatment even in women at high risk of OHSS. However to date, the safety of kisspeptin has not been compared to current hormonal triggers of oocyte maturation. Design.  We conducted a retrospective single-centre cohort study investigating symptoms and clinical parameters of early OHSS in women at high risk of OHSS (antral follicle count or total number of follicles on day of trigger ≥23) triggered with hCG (n=40), GnRH agonist (GnRHa; n=99), or kisspeptin (n=122) at Hammersmith Hospital IVF unit, London, UK (2013-2016). Results.  Clinical Parameters of OHSS: Median ovarian volume was larger following hCG (138mls) than GnRHa (73mls; P<0.0001), and in turn kisspeptin (44mls; P<0.0001). Median ovarian volume remained enlarged 20-fold following hCG, 8-fold following GnRHa and 5-fold following kisspeptin compared to pre-stimulation ovarian volumes. Mean (±SD) ascitic volumes were lesser following GnRHa (9±44mls) and kisspeptin (5±8mls) than hCG (62±84mls; p<0.0001). Symptoms of OHSS were most frequent following hCG and least frequent following kisspeptin. Diagnosis of OHSS: The odds ratio for OHSS diagnosis was 33·6 (CI 12·6-89·5) following hCG and 3·6 (CI 1·8-7·1) following GnRHa, when compared to kisspeptin. Conclusion.  Triggering oocyte maturation by inducing endogenous gonadotropin release is preferable to the use of exogenous hCG in women at high risk of OHSS.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofClinical Endocrinologyen
dc.rights© 2018 The Authors. Clinical Endocrinology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectGnRH agonisten
dc.subjecthCGen
dc.subjectIVFen
dc.subjectKisspeptinen
dc.subjectOvarian Hyperstimulation Syndromeen
dc.subjectQA75 Electronic computers. Computer scienceen
dc.subjectRG Gynecology and obstetricsen
dc.subjectNDASen
dc.subject.lccQA75en
dc.subject.lccRGen
dc.titleClinical parameters of ovarian hyperstimulation syndrome (OHSS) following different triggers of oocyte maturation in IVF treatmenten
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews.Centre for Interdisciplinary Research in Computational Algebraen
dc.identifier.doihttps://doi.org/10.1111/cen.13569
dc.description.statusPeer revieweden


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