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dc.contributor.authorEendebak, Robert J. A. H.
dc.contributor.authorSwiecicka, Agnieszka
dc.contributor.authorGromski, Piotr S.
dc.contributor.authorPye, Stephen R.
dc.contributor.authorO'Neill, Terence W.
dc.contributor.authorMarshall, Alan
dc.contributor.authorKeevil, Brian G.
dc.contributor.authorTampubolon, Gindo
dc.contributor.authorGoodacre, Royston
dc.contributor.authorWu, Frederick C. W.
dc.contributor.authorRutter, Martin K.
dc.date.accessioned2018-03-01T00:33:01Z
dc.date.available2018-03-01T00:33:01Z
dc.date.issued2017-05
dc.identifier.citationEendebak , R J A H , Swiecicka , A , Gromski , P S , Pye , S R , O'Neill , T W , Marshall , A , Keevil , B G , Tampubolon , G , Goodacre , R , Wu , F C W & Rutter , M K 2017 , ' Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men ' , Clinical Endocrinology , vol. 86 , no. 5 , pp. 660-668 . https://doi.org/10.1111/cen.13305en
dc.identifier.issn1365-2265
dc.identifier.otherPURE: 249091558
dc.identifier.otherPURE UUID: f10d3141-c503-4425-a787-e8d2bb53bc61
dc.identifier.otherBibtex: urn:2efee72ffab3f092e1a0151b727ad842
dc.identifier.otherScopus: 85014283125
dc.identifier.otherWOS: 000398856100004
dc.identifier.urihttp://hdl.handle.net/10023/12820
dc.descriptionRJAHE is supported by a Biotechnology and Biological Sciences Research Council – Doctoral Training Partnership (BBSRC-DTP) PhD-fellowship, and is grateful for receiving support from the Fundatie van de Vrijvrouwe van Renswoude and Scholten-Cordes scholarship foundations. All authors would like to thank the men who participated in the HUSERMET-project (10) and are grateful for funding of the HUSERMET project by the U.K. BBSRC (Grant number: BB/C519038/1) and U.K. Medical Research Council, with contributions from Astra-Zeneca and GlaxoSmithKline.en
dc.description.abstractObjectives: To assess ethnic differences in male reproductive hormone levels and to determine if any differences are explained by adiposity, insulin resistance (IR), or comorbidities in older men. Design: Multi-ethnic cross-sectional observational study. Participants: Community dwelling middle-aged and elderly men residing in the U.K. aged 40-84 years of South Asian (SA; n=180), White European (WE; n=328) or African Caribbean (AC; n=166) origin. Observations: Measured testosterone (T), calculated free T (cFT), SHBG, and LH in SA, WE and AC men along with an assessment of body composition, IR, life-style factors and medical conditions. Results: Age-adjusted mean T and cFT levels were lower in SA men when compared to WE and AC men (mean (SEM) T: SA: 14·0 ± 0·4; WE: 17·1 ± 0·3; AC: 17·2 ± 0·5 nmol/l, P < 0·001; cFT: SA: 283 ± 7; WE: 313 ± 5; AC: 314 ± 8 pmol/l, P < 0·006). Compared to WE and AC men, SA men had higher levels of body fat, IR, comorbidities and diabetes. After adjusting for body fat, IR and other confounders, T levels in SA men remained lower than in WE men (P = 0·04) but ethnic differences in cFT became nonsignificant. LH levels were higher in SA than WE men in age-adjusted and fully adjusted models. Conclusions: T and cFT are lower in SA men than in WE and AC men. Whether ethnic-specific reference ranges for T and cFT might be appropriate in clinical practice requires further investigation. Ethnic differences in cFT, but not T, appear to be, more readily, explained by ethnic differences in adiposity, thus providing insights into potential pathophysiological mechanisms.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofClinical Endocrinologyen
dc.rights© 2017 Crown copyright. Clinical Endocrinology © 2017 John Wiley & Sons Ltd. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at: https://doi.org/10.1111/cen.13305en
dc.subjectQH426 Geneticsen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQH426en
dc.subject.lccRA0421en
dc.subject.lccQDen
dc.titleEthnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older menen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.Geography & Sustainable Developmenten
dc.identifier.doihttps://doi.org/10.1111/cen.13305
dc.description.statusPeer revieweden
dc.date.embargoedUntil2018-02-28
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/cen.13305/abstract#footer-support-infoen


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