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dc.contributor.authorAnastasiou, A. D.
dc.contributor.authorStrafford, S.
dc.contributor.authorPosada-Estefan, O.
dc.contributor.authorThomson, C. L.
dc.contributor.authorHussaein, S. A.
dc.contributor.authorEdwards, T. J.
dc.contributor.authorMalinowski, M.
dc.contributor.authorHondow, N.
dc.contributor.authorMetzger, N. K.
dc.contributor.authorBrown, C. T. A.
dc.contributor.authorRoutledge, M. N.
dc.contributor.authorBrown, A. P.
dc.contributor.authorDuggal, M. S.
dc.contributor.authorJha, A.
dc.identifier.citationAnastasiou , A D , Strafford , S , Posada-Estefan , O , Thomson , C L , Hussaein , S A , Edwards , T J , Malinowski , M , Hondow , N , Metzger , N K , Brown , C T A , Routledge , M N , Brown , A P , Duggal , M S & Jha , A 2017 , ' β-pyrophosphate : a potential biomaterial for dental applications ' Materials Science and Engineering: B , vol. 75 , pp. 885-894 .
dc.identifier.otherPURE: 249221833
dc.identifier.otherPURE UUID: 425a4926-6532-45a7-96ac-408aeed3d932
dc.identifier.otherRIS: urn:F669C5D5BCC428DB42FC2EEB8B27D942
dc.identifier.otherScopus: 85014296745
dc.descriptionThe authors acknowledge support from the sponsors of this work; the EPSRC LUMIN (EP/K020234/1) and EU-Marie-Curie-IAPP LUSTRE (324538) projects.en
dc.description.abstractTooth hypersensitivity is a growing problem affecting both the young and ageing population worldwide. Since an effective and permanent solution is not yet available, we propose a new methodology for the restoration of dental enamel using femtosecond lasers and novel calcium phosphate biomaterials. During this procedure the irradiated mineral transforms into a densified layer of acid resistant iron doped β-pyrophosphate, bonded with the surface of eroded enamel. Our aim therefore is to evaluate this densified mineral as a potential replacement material for dental hard tissue. To this end, we have tested the hardness of β-pyrophosphate pellets (sintered at 1000 °C) and its mineral precursor (brushite), the wear rate during simulated tooth-brushing trials and the cytocompatibility of these minerals in powder form. It was found that the hardness of the β-pyrophosphate pellets is comparable with that of dental enamel and significantly higher than dentine while, the brushing trials prove that the wear rate of β-pyrophosphate is much slower than that of natural enamel. Finally, cytotoxicity and genotoxicity tests suggest that iron doped β-pyrophosphate is cytocompatible and therefore could be used in dental applications. Taken together and with the previously reported results on laser irradiation of these materials we conclude that iron doped β-pyrophosphate may be a promising material for restoring acid eroded and worn enamel.en
dc.relation.ispartofMaterials Science and Engineering: Ben
dc.rights© 2017 Elsevier Ltd. All rights reserved. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at
dc.subjectCalcium phosphateen
dc.subjectEnamel restorationen
dc.subjectDental biomaterialsen
dc.subjectIron dopingen
dc.subjectQC Physicsen
dc.subjectQD Chemistryen
dc.subjectRK Dentistryen
dc.titleβ-pyrophosphate : a potential biomaterial for dental applicationsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.description.statusPeer revieweden

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