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β-pyrophosphate : a potential biomaterial for dental applications
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dc.contributor.author | Anastasiou, A. D. | |
dc.contributor.author | Strafford, S. | |
dc.contributor.author | Posada-Estefan, O. | |
dc.contributor.author | Thomson, C. L. | |
dc.contributor.author | Hussaein, S. A. | |
dc.contributor.author | Edwards, T. J. | |
dc.contributor.author | Malinowski, M. | |
dc.contributor.author | Hondow, N. | |
dc.contributor.author | Metzger, N. K. | |
dc.contributor.author | Brown, C. T. A. | |
dc.contributor.author | Routledge, M. N. | |
dc.contributor.author | Brown, A. P. | |
dc.contributor.author | Duggal, M. S. | |
dc.contributor.author | Jha, A. | |
dc.date.accessioned | 2018-02-25T00:32:54Z | |
dc.date.available | 2018-02-25T00:32:54Z | |
dc.date.issued | 2017-06-01 | |
dc.identifier | 249221833 | |
dc.identifier | 425a4926-6532-45a7-96ac-408aeed3d932 | |
dc.identifier | 85014296745 | |
dc.identifier | 000400720800103 | |
dc.identifier.citation | Anastasiou , A D , Strafford , S , Posada-Estefan , O , Thomson , C L , Hussaein , S A , Edwards , T J , Malinowski , M , Hondow , N , Metzger , N K , Brown , C T A , Routledge , M N , Brown , A P , Duggal , M S & Jha , A 2017 , ' β-pyrophosphate : a potential biomaterial for dental applications ' , Materials Science and Engineering: B , vol. 75 , pp. 885-894 . https://doi.org/10.1016/j.msec.2017.02.116 | en |
dc.identifier.issn | 0928-4931 | |
dc.identifier.other | RIS: urn:F669C5D5BCC428DB42FC2EEB8B27D942 | |
dc.identifier.other | ORCID: /0000-0002-4405-6677/work/86537104 | |
dc.identifier.uri | https://hdl.handle.net/10023/12777 | |
dc.description | The authors acknowledge support from the sponsors of this work; the EPSRC LUMIN (EP/K020234/1) and EU-Marie-Curie-IAPP LUSTRE (324538) projects. | en |
dc.description.abstract | Tooth hypersensitivity is a growing problem affecting both the young and ageing population worldwide. Since an effective and permanent solution is not yet available, we propose a new methodology for the restoration of dental enamel using femtosecond lasers and novel calcium phosphate biomaterials. During this procedure the irradiated mineral transforms into a densified layer of acid resistant iron doped β-pyrophosphate, bonded with the surface of eroded enamel. Our aim therefore is to evaluate this densified mineral as a potential replacement material for dental hard tissue. To this end, we have tested the hardness of β-pyrophosphate pellets (sintered at 1000 °C) and its mineral precursor (brushite), the wear rate during simulated tooth-brushing trials and the cytocompatibility of these minerals in powder form. It was found that the hardness of the β-pyrophosphate pellets is comparable with that of dental enamel and significantly higher than dentine while, the brushing trials prove that the wear rate of β-pyrophosphate is much slower than that of natural enamel. Finally, cytotoxicity and genotoxicity tests suggest that iron doped β-pyrophosphate is cytocompatible and therefore could be used in dental applications. Taken together and with the previously reported results on laser irradiation of these materials we conclude that iron doped β-pyrophosphate may be a promising material for restoring acid eroded and worn enamel. | |
dc.format.extent | 10 | |
dc.format.extent | 2302242 | |
dc.language.iso | eng | |
dc.relation.ispartof | Materials Science and Engineering: B | en |
dc.subject | Calcium phosphate | en |
dc.subject | Enamel restoration | en |
dc.subject | Dental biomaterials | en |
dc.subject | Sintering | en |
dc.subject | Iron doping | en |
dc.subject | QC Physics | en |
dc.subject | QD Chemistry | en |
dc.subject | RK Dentistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QC | en |
dc.subject.lcc | QD | en |
dc.subject.lcc | RK | en |
dc.title | β-pyrophosphate : a potential biomaterial for dental applications | en |
dc.type | Journal article | en |
dc.contributor.sponsor | European Commission | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.identifier.doi | 10.1016/j.msec.2017.02.116 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2018-02-24 | |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0928493116319129 | en |
dc.identifier.grantnumber | 324538 | en |
dc.identifier.grantnumber | en |
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