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One-pot homologation of boronic acids

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dc.contributor.authorMuir, Calum W.
dc.contributor.authorVantourout, Julien C.
dc.contributor.authorIsidro-Llobet, Albert
dc.contributor.authorMacdonald, Simon J. F.
dc.contributor.authorWatson, Allan J. B.
dc.date.accessioned2018-02-07T11:30:08Z
dc.date.available2018-02-07T11:30:08Z
dc.date.issued2015-12-18
dc.identifier.citationMuir , C W , Vantourout , J C , Isidro-Llobet , A , Macdonald , S J F & Watson , A J B 2015 , ' One-pot homologation of boronic acids ' , Organic Letters , vol. 17 , no. 24 , pp. 6030-6033 . https://doi.org/10.1021/acs.orglett.5b03030en
dc.identifier.issn1523-7060
dc.identifier.otherPURE: 252193053
dc.identifier.otherPURE UUID: b22f9cbc-80a6-4994-afed-10ddb70e1e29
dc.identifier.otherRIS: urn:41EBA69331F3B61C683D3F9ACF34A31D
dc.identifier.otherScopus: 84952644720
dc.identifier.otherORCID: /0000-0002-1582-4286/work/56639161
dc.identifier.urihttps://hdl.handle.net/10023/12684
dc.descriptionThis work was supported by the Engineering and Physical Sciences Research Council (EPSRC).en
dc.description.abstractFormal homologation of sp2-hybridized boronic acids is achieved via cross-coupling of boronic acids with conjunctive haloaryl BMIDA components in the presence of a suitably balanced basic phase. The utility of this approach to provide a platform for diversity-oriented synthesis in discovery medicinal chemistry is demonstrated in the context of the synthesis of a series of analogues of a BET bromodomain inhibitor.
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofOrganic Lettersen
dc.rights© 2015 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.en
dc.subjectBoronic acidsen
dc.subjectChemical reactivityen
dc.subjectOrganometallic reagentsen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleOne-pot homologation of boronic acidsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.identifier.doihttps://doi.org/10.1021/acs.orglett.5b03030
dc.description.statusPeer revieweden


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