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dc.contributor.authorRamsay, Rona R.
dc.contributor.authorPopovic-Nikolicb, Marija R.
dc.contributor.authorNikolic, Katarina
dc.contributor.authorUliassi, Elisa
dc.contributor.authorBolognesi, Maria Laura
dc.date.accessioned2018-01-17T16:30:08Z
dc.date.available2018-01-17T16:30:08Z
dc.date.issued2018-01-17
dc.identifier.citationRamsay , R R , Popovic-Nikolicb , M R , Nikolic , K , Uliassi , E & Bolognesi , M L 2018 , ' A perspective on multi-target drug discovery and design for complex diseases ' , Clinical and Translational Medicine , vol. 7 , 3 . https://doi.org/10.1186/s40169-017-0181-2en
dc.identifier.issn2001-1326
dc.identifier.otherPURE: 252004081
dc.identifier.otherPURE UUID: d7f9d325-0c26-4c1d-b0b3-f2fd4bd7a499
dc.identifier.otherWOS: 000423130500001
dc.identifier.urihttp://hdl.handle.net/10023/12499
dc.descriptionKN and MPN acknowledge national project number 172033 supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia.en
dc.description.abstractDiseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists.
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofClinical and Translational Medicineen
dc.rights© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.subjectMulti-target drugsen
dc.subjectNeurodegenerationen
dc.subjectCanceren
dc.subjectCheminformaticsen
dc.subjectVirtual screeningen
dc.subjectBiological assaysen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQD Chemistryen
dc.subject.lccRMen
dc.subject.lccRC0321en
dc.subject.lccRC0254en
dc.subject.lccQDen
dc.titleA perspective on multi-target drug discovery and design for complex diseasesen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1186/s40169-017-0181-2
dc.description.statusPeer revieweden


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