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The serotonergic system tracks the outcomes of actions to mediate short-term motor learning

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Date
03/11/2016
Author
Kawashima, Takashi
Zwart, Maarten F.
Yang, Chao-Tsung
Mensh, Brett
Ahrens, Misha
Keywords
Motor learning
Short-term memory
Imaging
Dorsal raphe nucleus
Serotonin
Serotonergic system
Neural circuits
Zebrafish
Neuromodulation
Neuroscience
QH301 Biology
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
DAS
BDC
R2C
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Abstract
To execute accurate movements, animals must continuously adapt their behavior to changes in their bodies and environments. Animals can learn changes in the relationship between their locomotor commands and the resulting distance moved, then adjust command strength to achieve a desired travel distance. It is largely unknown which circuits implement this form of motor learning, or how. Using whole-brain neuronal imaging and circuit manipulations in larval zebrafish, we discovered that the serotonergic dorsal raphe nucleus (DRN) mediates short-term locomotor learning. Serotonergic DRN neurons respond phasically to swim-induced visual motion, but little to motion that is not self-generated. During prolonged exposure to a given motosensory gain, persistent DRN activity emerges that stores the learned efficacy of motor commands and adapts future locomotor drive for tens of seconds. The DRN’s ability to track the effectiveness of motor intent may constitute a computational building block for the broader functions of the serotonergic system.
Citation
Kawashima , T , Zwart , M F , Yang , C-T , Mensh , B & Ahrens , M 2016 , ' The serotonergic system tracks the outcomes of actions to mediate short-term motor learning ' , Cell , vol. 167 , no. 4 , e20 , pp. 933-946 . https://doi.org/10.1016/j.cell.2016.09.055
Publication
Cell
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.cell.2016.09.055
ISSN
0092-8674
Type
Journal article
Rights
Copyright © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Description
This study was supported by the Howard Hughes Medical Institute and by the Simons Foundation award 325171.
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  • University of St Andrews Research
URL
http://www.sciencedirect.com/science/article/pii/S0092867416313794?via%3Dihub#app2
URI
http://hdl.handle.net/10023/12475

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