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dc.contributor.authorFushiki, Akira
dc.contributor.authorZwart, Maarten F.
dc.contributor.authorKohsaka, Hiroshi
dc.contributor.authorFetter, Richard D.
dc.contributor.authorCardona, Albert
dc.contributor.authorNose, Akinao
dc.date.accessioned2018-01-15T10:30:18Z
dc.date.available2018-01-15T10:30:18Z
dc.date.issued2016-03-31
dc.identifier.citationFushiki , A , Zwart , M F , Kohsaka , H , Fetter , R D , Cardona , A & Nose , A 2016 , ' A circuit mechanism for the propagation of waves of muscle contraction in Drosophila ' , eLife , vol. 5 , e13253 . https://doi.org/10.7554/eLife.13253.001en
dc.identifier.issn2050-084X
dc.identifier.otherPURE: 252028585
dc.identifier.otherPURE UUID: 78569832-22f1-4c6f-895d-71a2fcc3c907
dc.identifier.otherScopus: 84964227995
dc.identifier.otherORCID: /0000-0002-5073-8631/work/52572488
dc.identifier.urihttp://hdl.handle.net/10023/12474
dc.description.abstractAnimals move by adaptively coordinating the sequential activation of muscles. The circuit mechanisms underlying coordinated locomotion are poorly understood. Here, we report on a novel circuit for the propagation of waves of muscle contraction, using the peristaltic locomotion of Drosophila larvae as a model system. We found an intersegmental chain of synaptically connected neurons, alternating excitatory and inhibitory, necessary for wave propagation and active in phase with the wave. The excitatory neurons (A27h) are premotor and necessary only for forward locomotion, and are modulated by stretch receptors and descending inputs. The inhibitory neurons (GDL) are necessary for both forward and backward locomotion, suggestive of different yet coupled central pattern generators, and its inhibition is necessary for wave propagation. The circuit structure and functional imaging indicated that the commands to contract one segment promote the relaxation of the next segment, revealing a mechanism for wave propagation in peristaltic locomotion.
dc.format.extent23
dc.language.isoeng
dc.relation.ispartofeLifeen
dc.rights© 2016, Fushiki et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en
dc.subjectQH301 Biologyen
dc.subjectQL Zoologyen
dc.subjectNDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccQH301en
dc.subject.lccQLen
dc.titleA circuit mechanism for the propagation of waves of muscle contraction in Drosophilaen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.identifier.doihttps://doi.org/10.7554/eLife.13253.001
dc.description.statusPeer revieweden


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