Room temperature regioselective catalytic hydrodefluorination of fluoroarenes with trans-[Ru(NHC)4H2] through a concerted nucleophilic Ru−H attack pathway
Abstract
The efficient and highly selective room temperature hydrodefluorination (HDF) of fluoroarenes by the trans-[Ru(IMe4)4H2] catalyst, 3 , is reported. Mechanistic studies show 3 acts directly in catalysis without any ligand dissociation and DFT calculations indicate a concerted nucleophilic attack mechanism. The calculations fully account for the observed selectivities which corroborate earlier predictions regarding the selectivity of HDF.
Citation
Cybulski , M K , McKay , D , Macgregor , S A , Mahon , M F & Whittlesey , M K 2017 , ' Room temperature regioselective catalytic hydrodefluorination of fluoroarenes with trans-[Ru(NHC)4H2] through a concerted nucleophilic Ru−H attack pathway ' , Angewandte Chemie International Edition , vol. 56 , no. 6 , pp. 1515-1519 . https://doi.org/10.1002/anie.201610820
Publication
Angewandte Chemie International Edition
Status
Peer reviewed
ISSN
1521-3773Type
Journal article
Description
The authors acknowledge the EPSRC (grant EP/J009962/1, DTA) for financial supportCollections
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