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dc.contributor.authorSomorjai, Ildiko Maureen Lara
dc.date.accessioned2017-12-21T12:30:22Z
dc.date.available2017-12-21T12:30:22Z
dc.date.issued2017-12-21
dc.identifier.citationSomorjai , I M L 2017 , ' Amphioxus regeneration : evolutionary and biomedical implications ' , International Journal of Developmental Biology , vol. 61 , no. 10/11/12 , pp. 689-696 . https://doi.org/10.1387/ijdb.170219isen
dc.identifier.issn0214-6282
dc.identifier.otherPURE: 250513394
dc.identifier.otherPURE UUID: 3404e7aa-3814-40d7-884a-ce5a4a209df9
dc.identifier.otherScopus: 85039741549
dc.identifier.otherWOS: 000418431600013
dc.identifier.urihttp://hdl.handle.net/10023/12374
dc.descriptionFunding: Wellcome Trust ISSF, EU Horizon 2020 projects CORBEL and ASSEMBLE+, and the RS MacDonald Charitable Trust.en
dc.description.abstractRegeneration is a variable trait in chordates, with some species capable of impressive abilities, and others of only wound healing with scarring. Regenerative capacity has been reported in the literature for 5 species from two cephalochordate genera, Branchiostoma and Asymmetron. Its cellular and molecular bases have been studied in some detail in only two species: tail regeneration in the European amphioxus B. lanceolatum; and oral cirrus regeneration in the Asian species B. japonicum. Gene expression analyses of germline formation and posterior elongation in cephalochordate embryos provide some insight into regulation of progenitor and stem cell function. When combined with functional studies of gene function, including overexpression and knockdown, these will open the door to amphioxus as a good model not only for understanding the evolution of regeneration, but also for biomedical purposes.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofInternational Journal of Developmental Biologyen
dc.rightsCopyright (c) 2017 UPV/EHU Press This is the final published version of the work which was originally published at https://doi.org/10.1387/ijdb.170219isen
dc.subjectAmphioxusen
dc.subjectCephalochordateen
dc.subjectRegenerationen
dc.subjectChordateen
dc.subjectStem cellen
dc.subjectQH426 Geneticsen
dc.subject.lccQH426en
dc.titleAmphioxus regeneration : evolutionary and biomedical implicationsen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.identifier.doihttps://doi.org/10.1387/ijdb.170219is
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-12-01
dc.identifier.urlhttp://www.ijdb.ehu.es/web/paper/170219is/amphioxus-regeneration-evolutionary-and-biomedical-implications-en


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