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dc.contributor.authorBaldacchino, A.
dc.contributor.authorArmanyous, M.
dc.contributor.authorBalfour, D. J. K.
dc.contributor.authorHumphris, G.
dc.contributor.authorMatthews, K.
dc.identifier.citationBaldacchino , A , Armanyous , M , Balfour , D J K , Humphris , G & Matthews , K 2017 , ' Neuropsychological functioning and chronic methadone use : a systematic review and meta-analysis ' Neuroscience and Biobehavioral Reviews , vol 73 , pp. 23-38 . DOI: 10.1016/j.neubiorev.2016.11.008en
dc.identifier.otherPURE: 247517630
dc.identifier.otherPURE UUID: 7c696cea-5b62-4ef7-aede-11670aa39bd7
dc.identifier.otherScopus: 85006785017
dc.descriptionThe authors would like to thank the NHS Fife Research and Development Department for supporting this project.en
dc.description.abstractIntroduction: There is a presumption that neurocognition is commonly impaired in chronicmethadone exposed individuals (CM) when compared with healthy controls (HP).Additionally, it remains unclear if short term (< 1 year) abstinence (AP) is associated with an altered cognitive profile when compared with CM. Method: A random effect model approach was used on data assembled into the Comprehensive Meta-Analysis programme.Cohen’s d effect sizes and a significance levels of p<0.01 were calculated for each domain. Results: Data from a total cohort of 1063 CM, 412 AP and 879 HP participants, from 23 independent studies indicate global impairments in neurocognitive function in CM relative to HP participants. The smaller body of evidence comparing CM to AP participants is inconclusive. Conclusion: Methodological issues such as small sample sizes, heterogeneity and poor quality limited the interpretation of the results and does not address whether the observed impairments reflect co-morbid functioning, methadone-related sedation and/or other factors. Only higher quality longitudinal studies will permit confident interpretation of the results observed in this meta-analysis.en
dc.relation.ispartofNeuroscience and Biobehavioral Reviewsen
dc.rights© 2016, International Behavioural Society. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at /
dc.subjectOpioid dependenceen
dc.subjectCognitive impairmentsen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleNeuropsychological functioning and chronic methadone use : a systematic review and meta-analysisen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. WHO Collaborating Centre for International Child & Adolescent Health Policyen
dc.contributor.institutionUniversity of St Andrews. Health Psychologyen
dc.contributor.institutionUniversity of St Andrews. St Andrews Sustainability Instituteen
dc.contributor.institutionUniversity of St Andrews. Centre for Minorities Research (CMR)en
dc.description.statusPeer revieweden

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