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dc.contributor.authorHenderson, Audrey J.
dc.contributor.authorLasselin, Julie
dc.contributor.authorLekander, Mats
dc.contributor.authorOlsson, Mats J
dc.contributor.authorPowis, Simon J.
dc.contributor.authorAxelsson, John
dc.contributor.authorPerrett, David I.
dc.date.accessioned2017-11-13T00:33:57Z
dc.date.available2017-11-13T00:33:57Z
dc.date.issued2017-02
dc.identifier.citationHenderson , A J , Lasselin , J , Lekander , M , Olsson , M J , Powis , S J , Axelsson , J & Perrett , D I 2017 , ' Skin colour changes during experimentally-induced sickness ' , Brain, Behavior, and Immunity , vol. 60 . https://doi.org/10.1016/j.bbi.2016.11.008en
dc.identifier.issn0889-1591
dc.identifier.otherPURE: 247648934
dc.identifier.otherPURE UUID: ac920eec-cd7b-44b7-bb85-f9fe805bdefd
dc.identifier.otherRIS: urn:95C77B6E07455C0E840218B318A635E0
dc.identifier.otherScopus: 85007008799
dc.identifier.otherORCID: /0000-0003-4218-2984/work/60195300
dc.identifier.otherWOS: 000391908200032
dc.identifier.otherORCID: /0000-0002-6025-0939/work/64360928
dc.identifier.urihttp://hdl.handle.net/10023/12060
dc.descriptionThis project was supported by Swedish foundation for humanities and social sciences and a British Academy Wolfson Foundation Research Professorship grant. AH is supported by a studentship from the Biotechnology and Biological Sciences Research Council.en
dc.description.abstractSkin colour may be an important cue to detect sickness in humans but how skin colour changes with acute sickness is currently unknown. To determine possible colour changes, 22 healthy Caucasian participants were injected twice, once with lipopolysaccharide (LPS, at a dose of 2 ng/kg body weight) and once with placebo (saline), in a randomised cross-over design study. Skin colour across 3 arm and 3 face locations was recorded spectrophotometrically over a period of 8 hours in terms of lightness (L∗), redness (a∗) and yellowness (b∗) in a manner that is consistent with human colour perception. In addition, carotenoid status was assessed as we predicted that a decrease it skin yellowness would reflect a drop in skin carotenoids. We found an early change in skin colouration 1-3 hours post LPS injection with facial skin becoming lighter and less red whilst arm skin become darker but also less red and less yellow. The LPS injection also caused a drop in plasma carotenoids from 3 hours onwards. However, the timing of the carotenoid changes was not consistent with the skin colour changes suggesting that other mechanisms, such as a reduction of blood perfusion, oxygenation or composition. This is the first experimental study characterising skin colour associated with acute illness, and shows that changes occur early in the development of the sickness response. Colour changes may serve as a cue to health, prompting actions from others in terms of care-giving or disease avoidance. Specific mechanisms underlying these colour changes require further investigation.
dc.language.isoeng
dc.relation.ispartofBrain, Behavior, and Immunityen
dc.rights© 2016 Elsevier Inc. All rights reserved. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at: https://doi.org/10.1016/j.bbi.2016.11.008en
dc.subjectSkin colouren
dc.subjectInflammationen
dc.subjectLipopolysaccharideen
dc.subjectSICKNESS responseen
dc.subjectSpectrophotometryen
dc.subjectCarotenoidsen
dc.subjectBlooden
dc.subjectBF Psychologyen
dc.subjectNDASen
dc.subject.lccBFen
dc.titleSkin colour changes during experimentally-induced sicknessen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews.East of Scotland Bioscience Doctoral Training Partnershipen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews.Centre for Social Learning & Cognitive Evolutionen
dc.contributor.institutionUniversity of St Andrews.Cellular Medicine Divisionen
dc.identifier.doihttps://doi.org/10.1016/j.bbi.2016.11.008
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-11-12


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