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Fluorometabolite biosynthesis : isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus

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dc.contributor.authorBartholomé, Axel
dc.contributor.authorJanso, Jeffrey E.
dc.contributor.authorReilly, Usa
dc.contributor.authorO'Hagan, David
dc.date.accessioned2017-11-08T00:33:15Z
dc.date.available2017-11-08T00:33:15Z
dc.date.issued2017-01-07
dc.identifier.citationBartholomé , A , Janso , J E , Reilly , U & O'Hagan , D 2017 , ' Fluorometabolite biosynthesis : isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus ' , Organic & Biomolecular Chemistry , vol. 15 , no. 1 , pp. 61-64 . https://doi.org/10.1039/C6OB02291Jen
dc.identifier.issn1477-0520
dc.identifier.otherPURE: 247570046
dc.identifier.otherPURE UUID: 064ce606-16dd-4143-be81-10a5ebad39fe
dc.identifier.otherScopus: 85006934321
dc.identifier.otherWOS: 000391698600006
dc.identifier.otherORCID: /0000-0002-0510-5552/work/68281210
dc.identifier.urihttps://hdl.handle.net/10023/12031
dc.description.abstractDeuterium and carbon-13 labelled glycerols have been fed to Streptomyces calvus fermentations and isotope incorporation into the fluorine containing antibiotic nucleocidin have been evaluated by 19F-NMR. A single deuterium atom was incorporated from [2H5]- and (R)-[2H2]- glycerol into C-5’ of the antibiotic, suggesting that an oxidation occurs at this carbon after ribose ring assembly from glycerol (pentose phosphate pathway), during nucleocidin biosynthesis.
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofOrganic & Biomolecular Chemistryen
dc.rights© 2016 the Authors. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at: https://doi.org/10.1039/C6OB02291Jen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleFluorometabolite biosynthesis : isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvusen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1039/C6OB02291J
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-11-07


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