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Fluorometabolite biosynthesis : isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus
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dc.contributor.author | Bartholomé, Axel | |
dc.contributor.author | Janso, Jeffrey E. | |
dc.contributor.author | Reilly, Usa | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2017-11-08T00:33:15Z | |
dc.date.available | 2017-11-08T00:33:15Z | |
dc.date.issued | 2017-01-07 | |
dc.identifier | 247570046 | |
dc.identifier | 064ce606-16dd-4143-be81-10a5ebad39fe | |
dc.identifier | 85006934321 | |
dc.identifier | 000391698600006 | |
dc.identifier.citation | Bartholomé , A , Janso , J E , Reilly , U & O'Hagan , D 2017 , ' Fluorometabolite biosynthesis : isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus ' , Organic & Biomolecular Chemistry , vol. 15 , no. 1 , pp. 61-64 . https://doi.org/10.1039/C6OB02291J | en |
dc.identifier.issn | 1477-0520 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/68281210 | |
dc.identifier.uri | https://hdl.handle.net/10023/12031 | |
dc.description.abstract | Deuterium and carbon-13 labelled glycerols have been fed to Streptomyces calvus fermentations and isotope incorporation into the fluorine containing antibiotic nucleocidin have been evaluated by 19F-NMR. A single deuterium atom was incorporated from [2H5]- and (R)-[2H2]- glycerol into C-5’ of the antibiotic, suggesting that an oxidation occurs at this carbon after ribose ring assembly from glycerol (pentose phosphate pathway), during nucleocidin biosynthesis. | |
dc.format.extent | 4 | |
dc.format.extent | 589056 | |
dc.format.extent | 2210663 | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | Fluorometabolite biosynthesis : isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1039/C6OB02291J | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2017-11-07 |
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