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dc.contributor.authorEl Issaoui, Meryam
dc.contributor.authorGiorgine, Veronica
dc.contributor.authorMamsen, Linn S.
dc.contributor.authorRechnitzer, Catherine
dc.contributor.authorBirkebæk, Niels
dc.contributor.authorClausen, Niels
dc.contributor.authorKelsey, Thomas William
dc.contributor.authorAndersen, Claus Yding
dc.identifier.citationEl Issaoui , M , Giorgine , V , Mamsen , L S , Rechnitzer , C , Birkebæk , N , Clausen , N , Kelsey , T W & Andersen , C Y 2016 , ' Effect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 years ' , Fertility and Sterility , vol. 106 , no. 7 , pp. 1757–1762.e1 .
dc.identifier.otherORCID: /0000-0002-8091-1458/work/27201524
dc.descriptionThe Child Cancer Foundation in Denmark, The Novo Nordisk Foundation and the EU interregional project ReproHigh/ReproUnion are thanked for having funded this study.en
dc.description.abstractObjective: To study the impact of first-line antineoplastic treatment on the ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse. Design: Retrospective case-control study. Setting: University hospitals. Patients: Sixty-three girls under the age of 18 years who underwent OTC before (group 1: 31 patients) and after (group 2: 32 patients) their initial cancer treatment. Intervention(s): None. Main Outcome Measure(s): Follicular densities (follicles/mm3) measured from an ovarian cortical biopsy before OTC. The ovarian volume (mL) of entire ovaries excised for OTC was also monitored. Result(s):There was no statistically significant difference in the mean age or follicular density between groups 1 and 2 (334 ± 476/mm3 vs. 327 ± 756/mm3). In contrast, the ovarian volume and total number of ovarian cortex chips cryopreserved were statistically significantly lower in patients who received gonadotoxic treatment before OTC (mean ± standard deviation [SD]: ovarian volume, 5.3 ± 3.1 mL vs. 2.9 ± 2.1 mL, respectively; number of cortex chips: 21.3 ± 8.1 vs. 15.2 ± 7.1, respectively). The reduction in the estimated ovarian reserve ranged from 10% to 20% in children to around 30% in adolescent girls (>10 years). Conclusion(s): Girls under the age of 10 tolerate a gonadotoxic insult better than adolescents, who may experience up to a 30% reduction in the ovarian reserve via first-line gonadotoxic treatment, which at present is considered to have little effect on the follicle pool. This information will improve counseling of young female cancer patients in deciding whether to undergo fertility preservation treatment.
dc.relation.ispartofFertility and Sterilityen
dc.subjectOvarian tissue cryopreservationen
dc.subjectFertility preservationen
dc.subjectOvarian volumeen
dc.subjectFollicle densityen
dc.subjectQA75 Electronic computers. Computer scienceen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectRG Gynecology and obstetricsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleEffect of first line cancer treatment on the ovarian reserve and follicular density in girls under the age of 18 yearsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews. Centre for Interdisciplinary Research in Computational Algebraen
dc.description.statusPeer revieweden

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