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dc.contributor.authorFischer, M.
dc.contributor.authorTriggs, G. J.
dc.contributor.authorKrauss, T. F.
dc.date.accessioned2017-10-04T16:30:27Z
dc.date.available2017-10-04T16:30:27Z
dc.date.issued2016-03
dc.identifier.citationFischer , M , Triggs , G J & Krauss , T F 2016 , ' Optical sensing of microbial life on surfaces ' , Applied and Environmental Microbiology , vol. 82 , no. 5 , pp. 1362-1371 . https://doi.org/10.1128/AEM.03001-15en
dc.identifier.issn0099-2240
dc.identifier.otherPURE: 251276634
dc.identifier.otherPURE UUID: 639643e6-4aa2-471f-90e4-66281ebcdad5
dc.identifier.otherScopus: 84961191729
dc.identifier.otherPubMed: 26637605
dc.identifier.urihttps://hdl.handle.net/10023/11800
dc.descriptionEngineering and Physical Sciences Research Council (EPSRC) provided funding to Graham Triggs under grant number EP/J01771X/1. Biotechnology and Biological Sciences Research Council (BBSRC) provided funding to Matthias Fischer under grant number BB/L018160/1.en
dc.description.abstractThe label-free detection of microbial cells attached to a surface is an active field of research. The field is driven by the need to understand and control the growth of biofilms in a number of applications, including basic research in natural environments, industrial facilities, and clinical devices, to name a few. Despite significant progress in the ability to monitor the growth of biofilms and related living cells, the sensitivity and selectivity of such sensors are still a challenge. We believe that among the many different technologies available for monitoring biofilm growth, optical techniques are the most promising, as they afford direct imaging and offer high sensitivity and specificity. Furthermore, as each technique offers different insights into the biofilm growth mechanism, our analysis allows us to provide an overview of the biological processes at play. In addition, we use a set of key parameters to compare state-of-the-art techniques in the field, including a critical assessment of each method, to identify the most promising types of sensors. We highlight the challenges that need to be overcome to improve the characteristics of current biofilm sensor technologies and indicate where further developments are required. In addition, we provide guidelines for selecting a suitable sensor for detecting microbial cells on a surface.
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofApplied and Environmental Microbiologyen
dc.rightsCopyright © 2016 Fischer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.en
dc.subjectQH301 Biologyen
dc.subjectQR Microbiologyen
dc.subjectBiotechnologyen
dc.subjectFood Scienceen
dc.subjectApplied Microbiology and Biotechnologyen
dc.subjectEcologyen
dc.subjectNDASen
dc.subject.lccQH301en
dc.subject.lccQRen
dc.titleOptical sensing of microbial life on surfacesen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.identifier.doihttps://doi.org/10.1128/AEM.03001-15
dc.description.statusPeer revieweden
dc.identifier.grantnumberEP/J01771X/1en


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