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dc.contributor.authorDrummond, Nicola
dc.contributor.authorDavies, Nick
dc.contributor.authorLovett, Janet Eleanor
dc.contributor.authorMiller, Mark
dc.contributor.authorCook, Graeme
dc.contributor.authorBecker, Thomas
dc.contributor.authorBecker, Catherina
dc.contributor.authorMcPhail, Donald
dc.contributor.authorKunath, Tilo
dc.date.accessioned2017-09-25T11:30:14Z
dc.date.available2017-09-25T11:30:14Z
dc.date.issued2017-09-19
dc.identifier.citationDrummond , N , Davies , N , Lovett , J E , Miller , M , Cook , G , Becker , T , Becker , C , McPhail , D & Kunath , T 2017 , ' A synthetic cell permeable antioxidant protects neurons against acute oxidative stress ' , Scientific Reports , vol. 7 , 11857 . https://doi.org/10.1038/s41598-017-12072-5en
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 251025634
dc.identifier.otherPURE UUID: a96b9303-ff79-4934-aa3d-be89461b96a8
dc.identifier.otherScopus: 85029872869
dc.identifier.otherORCID: /0000-0002-3561-450X/work/40301302
dc.identifier.otherWOS: 000411165100034
dc.identifier.urihttps://hdl.handle.net/10023/11736
dc.descriptionFunding: Royal Society University Fellowship and grant (RF 120645) (JEL).en
dc.description.abstractExcessive reactive oxygen species (ROS) can damage proteins, lipids, and DNA, which result in cell damage and death. The outcomes can be acute, as seen in stroke, or more chronic as observed in age-related diseases such as Parkinson’s disease. Here we investigate the antioxidant ability of a novel synthetic flavonoid, Proxison (7-decyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4-chromenone), using a range of in vitro and in vivo approaches. We show that, while it has radical scavenging ability on par with other flavonoids in a cell-free system, Proxison is orders of magnitude more potent than natural flavonoids at protecting neural cells against oxidative stress and is capable of rescuing damaged cells. The unique combination of a lipophilic hydrocarbon tail with a modified polyphenolic head group promotes efficient cellular uptake and moderate mitochondrial enrichment of Proxison. Importantly, in vivo administration of Proxison demonstrated effective and well tolerated neuroprotection against cell loss in a zebrafish model of dopaminergic neurodegeneration.
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofScientific Reportsen
dc.rights© The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectQH301 Biologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccQH301en
dc.subject.lccRC0321en
dc.titleA synthetic cell permeable antioxidant protects neurons against acute oxidative stressen
dc.typeJournal articleen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.sponsorThe Royal Societyen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1038/s41598-017-12072-5
dc.description.statusPeer revieweden
dc.identifier.grantnumberUF150698en
dc.identifier.grantnumberUF090121en


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