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A synthetic cell permeable antioxidant protects neurons against acute oxidative stress
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dc.contributor.author | Drummond, Nicola | |
dc.contributor.author | Davies, Nick | |
dc.contributor.author | Lovett, Janet Eleanor | |
dc.contributor.author | Miller, Mark | |
dc.contributor.author | Cook, Graeme | |
dc.contributor.author | Becker, Thomas | |
dc.contributor.author | Becker, Catherina | |
dc.contributor.author | McPhail, Donald | |
dc.contributor.author | Kunath, Tilo | |
dc.date.accessioned | 2017-09-25T11:30:14Z | |
dc.date.available | 2017-09-25T11:30:14Z | |
dc.date.issued | 2017-09-19 | |
dc.identifier.citation | Drummond , N , Davies , N , Lovett , J E , Miller , M , Cook , G , Becker , T , Becker , C , McPhail , D & Kunath , T 2017 , ' A synthetic cell permeable antioxidant protects neurons against acute oxidative stress ' , Scientific Reports , vol. 7 , 11857 . https://doi.org/10.1038/s41598-017-12072-5 | en |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | PURE: 251025634 | |
dc.identifier.other | PURE UUID: a96b9303-ff79-4934-aa3d-be89461b96a8 | |
dc.identifier.other | Scopus: 85029872869 | |
dc.identifier.other | ORCID: /0000-0002-3561-450X/work/40301302 | |
dc.identifier.other | WOS: 000411165100034 | |
dc.identifier.uri | https://hdl.handle.net/10023/11736 | |
dc.description | Funding: Royal Society University Fellowship and grant (RF 120645) (JEL). | en |
dc.description.abstract | Excessive reactive oxygen species (ROS) can damage proteins, lipids, and DNA, which result in cell damage and death. The outcomes can be acute, as seen in stroke, or more chronic as observed in age-related diseases such as Parkinson’s disease. Here we investigate the antioxidant ability of a novel synthetic flavonoid, Proxison (7-decyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4-chromenone), using a range of in vitro and in vivo approaches. We show that, while it has radical scavenging ability on par with other flavonoids in a cell-free system, Proxison is orders of magnitude more potent than natural flavonoids at protecting neural cells against oxidative stress and is capable of rescuing damaged cells. The unique combination of a lipophilic hydrocarbon tail with a modified polyphenolic head group promotes efficient cellular uptake and moderate mitochondrial enrichment of Proxison. Importantly, in vivo administration of Proxison demonstrated effective and well tolerated neuroprotection against cell loss in a zebrafish model of dopaminergic neurodegeneration. | |
dc.format.extent | 12 | |
dc.language.iso | eng | |
dc.relation.ispartof | Scientific Reports | en |
dc.rights | © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.subject | QH301 Biology | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | RC0321 | en |
dc.title | A synthetic cell permeable antioxidant protects neurons against acute oxidative stress | en |
dc.type | Journal article | en |
dc.contributor.sponsor | The Royal Society | en |
dc.contributor.sponsor | The Royal Society | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1038/s41598-017-12072-5 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | UF150698 | en |
dc.identifier.grantnumber | UF090121 | en |
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