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dc.contributor.authorYates, Lucy R.
dc.contributor.authorKnappskog, Stian
dc.contributor.authorWedge, David
dc.contributor.authorFarmery, James H. R.
dc.contributor.authorGonzalez, Santiago
dc.contributor.authorMartincorena, Inigo
dc.contributor.authorAlexandrov, Ludmil B.
dc.contributor.authorVan Loo, Peter
dc.contributor.authorHaugland, Hans Kristian
dc.contributor.authorLilleng, Peer Kaare
dc.contributor.authorGundem, Gunes
dc.contributor.authorGerstung, Moritz
dc.contributor.authorPappaemmanuil, Elli
dc.contributor.authorGazinska, Patrycja
dc.contributor.authorBhosle, Shriram G
dc.contributor.authorJones, David
dc.contributor.authorRaine, Keiran
dc.contributor.authorMudie, Laura
dc.contributor.authorLatimer, Calli
dc.contributor.authorSawyer, Elinor
dc.contributor.authorDesmedt, Christine
dc.contributor.authorSotiriou, Christos
dc.contributor.authorStratton, Michael R.
dc.contributor.authorSieuwerts, Anieta M.
dc.contributor.authorLynch, Andy G.
dc.contributor.authorMartens, John W.
dc.contributor.authorRichardson, Andrea L.
dc.contributor.authorTutt, Andrew
dc.contributor.authorLønning, Per Eystein
dc.contributor.authorCampbell, Peter J.
dc.identifier.citationYates , L R , Knappskog , S , Wedge , D , Farmery , J H R , Gonzalez , S , Martincorena , I , Alexandrov , L B , Van Loo , P , Haugland , H K , Lilleng , P K , Gundem , G , Gerstung , M , Pappaemmanuil , E , Gazinska , P , Bhosle , S G , Jones , D , Raine , K , Mudie , L , Latimer , C , Sawyer , E , Desmedt , C , Sotiriou , C , Stratton , M R , Sieuwerts , A M , Lynch , A G , Martens , J W , Richardson , A L , Tutt , A , Lønning , P E & Campbell , P J 2017 , ' Genomic evolution of breast cancer metastasis and relapse ' , Cancer Cell , vol. 32 , no. 2 , e7 , pp. 169-184 .
dc.identifier.otherPubMedCentral: PMC5559645
dc.identifier.otherORCID: /0000-0002-7876-7338/work/36476319
dc.descriptionA.G.L. and J.H.R.F. were supported by a Cancer Research UK Program Grant to Simon Tavaré (C14303/A17197).en
dc.description.abstractPatterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire mutations, mostly accessing the same mutational processes active in the primary tumor. Most distant metastases acquired driver mutations not seen in the primary tumor, drawing from a wider repertoire of cancer genes than early drivers. These include a number of clinically actionable alterations and mutations inactivating SWI-SNF and JAK2-STAT3 pathways.
dc.relation.ispartofCancer Cellen
dc.subjectBreast canceren
dc.subjectSomatic mutationen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQH301 Biologyen
dc.subjectQH426 Geneticsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleGenomic evolution of breast cancer metastasis and relapseen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Statisticsen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.description.statusPeer revieweden

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