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Genomic evolution of breast cancer metastasis and relapse
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dc.contributor.author | Yates, Lucy R. | |
dc.contributor.author | Knappskog, Stian | |
dc.contributor.author | Wedge, David | |
dc.contributor.author | Farmery, James H. R. | |
dc.contributor.author | Gonzalez, Santiago | |
dc.contributor.author | Martincorena, Inigo | |
dc.contributor.author | Alexandrov, Ludmil B. | |
dc.contributor.author | Van Loo, Peter | |
dc.contributor.author | Haugland, Hans Kristian | |
dc.contributor.author | Lilleng, Peer Kaare | |
dc.contributor.author | Gundem, Gunes | |
dc.contributor.author | Gerstung, Moritz | |
dc.contributor.author | Pappaemmanuil, Elli | |
dc.contributor.author | Gazinska, Patrycja | |
dc.contributor.author | Bhosle, Shriram G | |
dc.contributor.author | Jones, David | |
dc.contributor.author | Raine, Keiran | |
dc.contributor.author | Mudie, Laura | |
dc.contributor.author | Latimer, Calli | |
dc.contributor.author | Sawyer, Elinor | |
dc.contributor.author | Desmedt, Christine | |
dc.contributor.author | Sotiriou, Christos | |
dc.contributor.author | Stratton, Michael R. | |
dc.contributor.author | Sieuwerts, Anieta M. | |
dc.contributor.author | Lynch, Andy G. | |
dc.contributor.author | Martens, John W. | |
dc.contributor.author | Richardson, Andrea L. | |
dc.contributor.author | Tutt, Andrew | |
dc.contributor.author | Lønning, Per Eystein | |
dc.contributor.author | Campbell, Peter J. | |
dc.date.accessioned | 2017-08-28T10:30:08Z | |
dc.date.available | 2017-08-28T10:30:08Z | |
dc.date.issued | 2017-08-14 | |
dc.identifier.citation | Yates , L R , Knappskog , S , Wedge , D , Farmery , J H R , Gonzalez , S , Martincorena , I , Alexandrov , L B , Van Loo , P , Haugland , H K , Lilleng , P K , Gundem , G , Gerstung , M , Pappaemmanuil , E , Gazinska , P , Bhosle , S G , Jones , D , Raine , K , Mudie , L , Latimer , C , Sawyer , E , Desmedt , C , Sotiriou , C , Stratton , M R , Sieuwerts , A M , Lynch , A G , Martens , J W , Richardson , A L , Tutt , A , Lønning , P E & Campbell , P J 2017 , ' Genomic evolution of breast cancer metastasis and relapse ' , Cancer Cell , vol. 32 , no. 2 , e7 , pp. 169-184 . https://doi.org/10.1016/j.ccell.2017.07.005 | en |
dc.identifier.issn | 1535-6108 | |
dc.identifier.other | PURE: 250951438 | |
dc.identifier.other | PURE UUID: 63f91edd-c9f0-43b7-95cf-f90bded7d6f9 | |
dc.identifier.other | PubMed: 28810143 | |
dc.identifier.other | PubMedCentral: PMC5559645 | |
dc.identifier.other | Scopus: 85026812661 | |
dc.identifier.other | ORCID: /0000-0002-7876-7338/work/36476319 | |
dc.identifier.uri | https://hdl.handle.net/10023/11553 | |
dc.description | A.G.L. and J.H.R.F. were supported by a Cancer Research UK Program Grant to Simon Tavaré (C14303/A17197). | en |
dc.description.abstract | Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire mutations, mostly accessing the same mutational processes active in the primary tumor. Most distant metastases acquired driver mutations not seen in the primary tumor, drawing from a wider repertoire of cancer genes than early drivers. These include a number of clinically actionable alterations and mutations inactivating SWI-SNF and JAK2-STAT3 pathways. | |
dc.language.iso | eng | |
dc.relation.ispartof | Cancer Cell | en |
dc.rights | © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.subject | Breast cancer | en |
dc.subject | Metastasis | en |
dc.subject | Relapse | en |
dc.subject | Genomics | en |
dc.subject | Somatic mutation | en |
dc.subject | RC0254 Neoplasms. Tumors. Oncology (including Cancer) | en |
dc.subject | QH301 Biology | en |
dc.subject | QH426 Genetics | en |
dc.subject | DAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RC0254 | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | QH426 | en |
dc.title | Genomic evolution of breast cancer metastasis and relapse | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Statistics | en |
dc.contributor.institution | University of St Andrews. Population and Behavioural Science Division | en |
dc.contributor.institution | University of St Andrews. Cellular Medicine Division | en |
dc.identifier.doi | https://doi.org/10.1016/j.ccell.2017.07.005 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1535610817302970?via%3Dihub#app2 | en |
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