Show simple item record

Files in this item


Item metadata

dc.contributor.authorBehjati, Sam
dc.contributor.authorGundem, Gunes
dc.contributor.authorWedge, David C.
dc.contributor.authorRoberts, Nicola D.
dc.contributor.authorTarpey, Patrick S.
dc.contributor.authorCooke, Susanna L.
dc.contributor.authorVan Loo, Peter
dc.contributor.authorAlexandrov, Ludmil B.
dc.contributor.authorRamakrishna, Manasa
dc.contributor.authorDavies, Helen
dc.contributor.authorNik-Zainal, Serena
dc.contributor.authorHardy, Claire
dc.contributor.authorLatimer, Calli
dc.contributor.authorRaine, Keiran M.
dc.contributor.authorStebbings, Lucy
dc.contributor.authorMenzies, Andy
dc.contributor.authorJones, David
dc.contributor.authorShepherd, Rebecca
dc.contributor.authorButler, Adam P.
dc.contributor.authorTeague, Jon W.
dc.contributor.authorJorgensen, Mette
dc.contributor.authorKhatri, Bhavisha
dc.contributor.authorPillay, Nischalan
dc.contributor.authorShlien, Adam
dc.contributor.authorFutreal, P. Andrew
dc.contributor.authorBadie, Christophe
dc.contributor.authorMcDermott, Ultan
dc.contributor.authorBova, G. Steven
dc.contributor.authorRichardson, Andrea L.
dc.contributor.authorFlanagan, Adrienne M.
dc.contributor.authorStratton, Michael R.
dc.contributor.authorCampbell, Peter J.
dc.contributor.authorICGC Prostate Group
dc.identifier.citationBehjati , S , Gundem , G , Wedge , D C , Roberts , N D , Tarpey , P S , Cooke , S L , Van Loo , P , Alexandrov , L B , Ramakrishna , M , Davies , H , Nik-Zainal , S , Hardy , C , Latimer , C , Raine , K M , Stebbings , L , Menzies , A , Jones , D , Shepherd , R , Butler , A P , Teague , J W , Jorgensen , M , Khatri , B , Pillay , N , Shlien , A , Futreal , P A , Badie , C , McDermott , U , Bova , G S , Richardson , A L , Flanagan , A M , Stratton , M R , Campbell , P J & ICGC Prostate Group 2016 , ' Mutational signatures of ionizing radiation in second malignancies ' , Nature Communications , vol. 7 , 12605 .
dc.identifier.otherPURE: 250847176
dc.identifier.otherPURE UUID: cbc9af17-4785-485d-8106-571c58af7603
dc.identifier.otherScopus: 84987750128
dc.identifier.otherORCID: /0000-0002-7876-7338/work/36106403
dc.descriptionSequencing data have been deposited at the European Genome-Phenome Archive (EGA,, which is hosted by the European Bioinformatics Institute; accession numbers EGAS00001000138; EGAS00001000147; EGAS00001000195.en
dc.description.abstractIonizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizing radiation in 12 radiation-associated second malignancies of different tumour types. Two signatures of somatic mutation characterize ionizing radiation exposure irrespective of tumour type. Compared with 319 radiation-naive tumours, radiation-associated tumours carry a median extra 201 deletions genome-wide, sized 1-100 base pairs often with microhomology at the junction. Unlike deletions of radiation-naive tumours, these show no variation in density across the genome or correlation with sequence context, replication timing or chromatin structure. Furthermore, we observe a significant increase in balanced inversions in radiation-associated tumours. Both small deletions and inversions generate driver mutations. Thus, ionizing radiation generates distinctive mutational signatures that explain its carcinogenic potential.
dc.relation.ispartofNature Communicationsen
dc.rights© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQH426 Geneticsen
dc.subjectQD Chemistryen
dc.subjectBiochemistry, Genetics and Molecular Biology(all)en
dc.subjectPhysics and Astronomy(all)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleMutational signatures of ionizing radiation in second malignanciesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Statisticsen
dc.description.statusPeer revieweden

This item appears in the following Collection(s)

Show simple item record