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dc.contributor.authorLipworth, S.
dc.contributor.authorHammond, R.J.H.
dc.contributor.authorBaron, V.O.
dc.contributor.authorHu, Y.
dc.contributor.authorCoates, A.
dc.contributor.authorGillespie, S.H.
dc.date.accessioned2017-08-15T08:44:04Z
dc.date.available2017-08-15T08:44:04Z
dc.date.issued2016-07
dc.identifier243086204
dc.identifier775c681d-bb2f-4924-a193-fbc17ce460c9
dc.identifier84975886716
dc.identifier000380756100018
dc.identifier.citationLipworth , S , Hammond , R J H , Baron , V O , Hu , Y , Coates , A & Gillespie , S H 2016 , ' Defining dormancy in mycobacterial disease ' , Tuberculosis , vol. 99 , pp. 131-142 . https://doi.org/10.1016/j.tube.2016.05.006en
dc.identifier.issn1472-9792
dc.identifier.otherRIS: urn:63041A17E6E48A58E48A7336BA33CA7B
dc.identifier.otherORCID: /0000-0001-6537-7712/work/39477816
dc.identifier.otherORCID: /0000-0003-3664-3641/work/157140933
dc.identifier.urihttps://hdl.handle.net/10023/11452
dc.descriptionThis work was supported by The University of St Andrews and the PreDiCT-TB consortium and the grant from the Innovative Medicines Initiative Joint Undertaking (www.imi.europa.eu) under grant agreement 115337.en
dc.description.abstractTuberculosis remains a threat to global health and recent attempts to shorten therapy have not succeeded mainly due to cases of clinical relapse. This has focussed attention on the importance of “dormancy” in tuberculosis. There are a number of different definitions of the term and a similar multiplicity of different in vitro and in vivo models. The danger with this is the implicit assumption of equivalence between the terms and models, which will make even more difficult to unravel this complex conundrum. In this review we summarise the main models and definitions and their impact on susceptibility of Mycobacterium tuberculosis. We also suggest a potential nomenclature for debate. Dormancy researchers agree that factors underpinning this phenomenon are complex and nuanced. If we are to make progress we must agree the terms to be used and be consistent in using them.
dc.format.extent12
dc.format.extent848271
dc.language.isoeng
dc.relation.ispartofTuberculosisen
dc.subjectMycobacterium tuberculosisen
dc.subjectDormancyen
dc.subjectLatencyen
dc.subjectPersistenceen
dc.subjectMycobacteriaen
dc.subjectR Medicine (General)en
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccR1en
dc.titleDefining dormancy in mycobacterial diseaseen
dc.typeJournal articleen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Global Health Implementation Groupen
dc.contributor.institutionUniversity of St Andrews. Gillespie Groupen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Infection Groupen
dc.identifier.doi10.1016/j.tube.2016.05.006
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-05-28
dc.identifier.grantnumberen


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