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dc.contributor.authorSvensson, Erik
dc.contributor.authorJeffreys, Hugo
dc.contributor.authorLi, Wenchang
dc.date.accessioned2017-07-24T16:30:09Z
dc.date.available2017-07-24T16:30:09Z
dc.date.issued2017-07-01
dc.identifier.citationSvensson , E , Jeffreys , H & Li , W 2017 , ' The modulation of two motor behaviors by persistent sodium currents in Xenopus laevis tadpoles ' Journal of Neurophysiology , vol. 118 , no. 1 , pp. 121-130 . https://doi.org/10.1152/jn.00755.2016en
dc.identifier.issn0022-3077
dc.identifier.otherPURE: 249465034
dc.identifier.otherPURE UUID: 0c9e407f-f32e-471b-a716-e0afaa8a4b43
dc.identifier.otherScopus: 85021760369
dc.identifier.urihttp://hdl.handle.net/10023/11277
dc.description.abstractPersistent sodium currents (INaP) are common in neuronal circuitries and have been implicated in several diseases, such as amyotrophic lateral sclerosis (ALS) and epilepsy. However, the role of INaP in the regulation of specific behaviors is still poorly understood. In this study we have characterized INaP and investigated its role in the swimming and struggling behavior of Xenopus tadpoles. INaP was identified in three groups of neurons, namely, sensory Rohon-Beard neurons (RB neurons), descending interneurons (dINs), and non-dINs (neurons rhythmically active in swimming). All groups of neurons expressed INaP, but the currents differed in decay time constants, amplitudes, and the membrane potential at which INaP peaked. Low concentrations (1 µM) of the INaP blocker riluzole blocked INaP ~30% and decreased the excitability of the three neuron groups without affecting spike amplitudes or cellular input resistances. Riluzole reduced the number of rebound spikes in dINs and depressed repetitive firing in RB neurons and non-dINs. At the behavior level, riluzole at 1 µM shortened fictive swimming episodes. It also reduced the number of action potentials neurons fired on each struggling cycle. The results show that INaP may play important modulatory roles in motor behaviors.
dc.language.isoeng
dc.relation.ispartofJournal of Neurophysiologyen
dc.rights© the American Physiological Society. Licensed under Creative Commons Attribution CC-BY 4.0.en
dc.subjectXenopus tadpoleen
dc.subjectMotor behaviouren
dc.subjectSpinal corden
dc.subjectSodium currentsen
dc.subjectRiluzoleen
dc.subjectQH301 Biologyen
dc.subjectQP Physiologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccQH301en
dc.subject.lccQPen
dc.subject.lccRC0321en
dc.titleThe modulation of two motor behaviors by persistent sodium currents in Xenopus laevis tadpolesen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1152/jn.00755.2016
dc.description.statusPeer revieweden


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