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Global and regional dissemination and evolution of Burkholderia pseudomallei
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dc.contributor.author | Chewapreecha, Claire | |
dc.contributor.author | Holden, Matthew T. G. | |
dc.contributor.author | Vehkala, Minna | |
dc.contributor.author | Välimäki, Niko | |
dc.contributor.author | Yang, Zhirong | |
dc.contributor.author | Harris, Simon R. | |
dc.contributor.author | Mather, Alison E. | |
dc.contributor.author | Tuanyok, Apichai | |
dc.contributor.author | De Smet, Birgit | |
dc.contributor.author | Le Hello, Simon | |
dc.contributor.author | Bizet, Chantal | |
dc.contributor.author | Mayo, Mark | |
dc.contributor.author | Wuthiekanun, Vanaporn | |
dc.contributor.author | Limmathurotsakul, Direk | |
dc.contributor.author | Phetsouvanh, Rattanaphone | |
dc.contributor.author | Spratt, Brian G. | |
dc.contributor.author | Corander, Jukka | |
dc.contributor.author | Keim, Paul | |
dc.contributor.author | Dougan, Gordon | |
dc.contributor.author | Dance, David A. B. | |
dc.contributor.author | Currie, Bart J. | |
dc.contributor.author | Parkhill, Julian | |
dc.contributor.author | Peacock, Sharon J. | |
dc.date.accessioned | 2017-07-23T23:34:39Z | |
dc.date.available | 2017-07-23T23:34:39Z | |
dc.date.issued | 2017-01-23 | |
dc.identifier.citation | Chewapreecha , C , Holden , M T G , Vehkala , M , Välimäki , N , Yang , Z , Harris , S R , Mather , A E , Tuanyok , A , De Smet , B , Le Hello , S , Bizet , C , Mayo , M , Wuthiekanun , V , Limmathurotsakul , D , Phetsouvanh , R , Spratt , B G , Corander , J , Keim , P , Dougan , G , Dance , D A B , Currie , B J , Parkhill , J & Peacock , S J 2017 , ' Global and regional dissemination and evolution of Burkholderia pseudomallei ' , Nature Microbiology , vol. 2 , 16263 . https://doi.org/10.1038/nmicrobiol.2016.263 | en |
dc.identifier.issn | 2058-5276 | |
dc.identifier.other | PURE: 249027996 | |
dc.identifier.other | PURE UUID: 7c8e0c1c-570b-4013-89a6-17200a8a0adb | |
dc.identifier.other | PubMed: 28112723 | |
dc.identifier.other | Scopus: 85010282468 | |
dc.identifier.other | ORCID: /0000-0002-4958-2166/work/60196491 | |
dc.identifier.other | WOS: 000398177800006 | |
dc.identifier.uri | https://hdl.handle.net/10023/11270 | |
dc.description.abstract | The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted. | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Microbiology | en |
dc.rights | © 2017, the Author(s). This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.nature.com / https://doi.org/10.1038/nmicrobiol.2016.263 | en |
dc.subject | QR Microbiology | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | DAS | en |
dc.subject | BDC | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QR | en |
dc.subject.lcc | RA0421 | en |
dc.title | Global and regional dissemination and evolution of Burkholderia pseudomallei | en |
dc.type | Journal article | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Infection Group | en |
dc.contributor.institution | University of St Andrews. Infection and Global Health Division | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1038/nmicrobiol.2016.263 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2017-07-23 |
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