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Metabolic reprogramming during the Trypanosoma brucei life cycle

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dc.contributor.authorSmith, Terry K.
dc.contributor.authorBringaud, Frédéric
dc.contributor.authorNolan, Derek P.
dc.contributor.authorFigueiredo, Luisa M.
dc.date.accessioned2017-07-11T14:30:09Z
dc.date.available2017-07-11T14:30:09Z
dc.date.issued2017-05-18
dc.identifier.citationSmith , T K , Bringaud , F , Nolan , D P & Figueiredo , L M 2017 , ' Metabolic reprogramming during the Trypanosoma brucei life cycle ' , F1000Research , vol. 6 , 683 . https://doi.org/10.12688/f1000research.10342.2en
dc.identifier.issn2046-1402
dc.identifier.otherPURE: 250484202
dc.identifier.otherPURE UUID: 2656b2fb-dde9-43e4-a7f9-5273aa73e2f7
dc.identifier.otherPubMedCentral: 5461901
dc.identifier.otherScopus: 85024481213
dc.identifier.urihttps://hdl.handle.net/10023/11184
dc.descriptionTKS is supported by the Wellcome Trust, the Biotechnology and Biological Sciences Research Council, the Engineering and Physical Sciences Research Council, the Medical Research Council (MR/M020118/1) and the European Community Seventh Framework Programme under grant agreement 602773 (Project KINDRED). FB is supported by the Centre National de la Recherche Scientifique (CNRS), the Université de Bordeaux, the Agence Nationale de la Recherche (ANR) through the GLYCONOV grant (ANR-15-CE15-0025-01) of the ‘Générique’ 2015 call and the Laboratoire d’Excellence (LabEx) ParaFrap (grant ANR-11-LABX-0024). DPN is supported by the Wellcome Trust and Science Foundation Ireland. LMF is supported by the Howard Hughes Medical Institute (55007419) and the Fundação para a Ciência e a Tecnologia (FCT) (PTDC/BIM-MET/4471/2014).en
dc.description.abstractCellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma brucei, is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism.
dc.language.isoeng
dc.relation.ispartofF1000Researchen
dc.rights© 2017 Smith TK et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectTrypanosoma bruceien
dc.subjectMetabolismen
dc.subjectAdaptationsen
dc.subjectQH301 Biologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQH301en
dc.titleMetabolic reprogramming during the Trypanosoma brucei life cycleen
dc.typeJournal itemen
dc.contributor.sponsorEuropean Commissionen
dc.contributor.sponsorMedical Research Councilen
dc.contributor.sponsorThe Wellcome Trusten
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.12688/f1000research.10342.2
dc.description.statusPeer revieweden
dc.identifier.urlhttps://f1000research.com/articles/6-683/v2en
dc.identifier.grantnumber602773en
dc.identifier.grantnumberMR/M020118/1en
dc.identifier.grantnumber093228/Z/10/Zen


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