Files in this item
Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers
Item metadata
dc.contributor.author | Zhang, Qingzhi | |
dc.contributor.author | Dall'Angelo, Sergio | |
dc.contributor.author | Fleming, Ian N. | |
dc.contributor.author | Schweiger, Lutz F. | |
dc.contributor.author | Zanda, Matteo | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2017-07-04T23:33:39Z | |
dc.date.available | 2017-07-04T23:33:39Z | |
dc.date.issued | 2016-07-25 | |
dc.identifier.citation | Zhang , Q , Dall'Angelo , S , Fleming , I N , Schweiger , L F , Zanda , M & O'Hagan , D 2016 , ' Last-step enzymatic [ 18 F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers ' , Chemistry - A European Journal , vol. 22 , no. 31 , pp. 10998–11004 . https://doi.org/10.1002/chem.201601361 | en |
dc.identifier.issn | 1521-3765 | |
dc.identifier.other | PURE: 244261593 | |
dc.identifier.other | PURE UUID: 86cc3506-1f1a-4684-be5b-c903ca067fac | |
dc.identifier.other | Bibtex: urn:a60426cbb295a36e5f8da8c8cfbdf064 | |
dc.identifier.other | Scopus: 84978919513 | |
dc.identifier.other | WOS: 000382885500039 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/68281312 | |
dc.identifier.uri | https://hdl.handle.net/10023/11146 | |
dc.description | We thank the Engineering and Physical Sciences Research Council, UK, for a research grant. | en |
dc.description.abstract | We report a last-step fluorinase-catalyzed [18F]-fluorination of a cysteine-containing RGD peptide. The peptide was attached through sulfur to a modified and more hydrophilic variant of the recently disclosed Barbas linker which was itself linked to a chloroadenosine moiety via a PEGylated chain. The fluorinase was able to use this construct as a substrate for a transhalogenation reaction to generate [18F]-radiolabeled RGD peptides, which retained high affinity to cancer-cell relevant αvβ3 integrins. | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemistry - A European Journal | en |
dc.rights | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1002/chem.201601361 | en |
dc.subject | 18F labeling | en |
dc.subject | Barbas linker | en |
dc.subject | Bioconjugation | en |
dc.subject | Chemical biology | en |
dc.subject | RGD peptide | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | QD | en |
dc.title | Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | EPSRC | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1002/chem.201601361 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2017-07-04 | |
dc.identifier.grantnumber | EP/I034734/1 | en |
dc.identifier.grantnumber | EP/M01262X/1 | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.