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Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers

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dc.contributor.authorZhang, Qingzhi
dc.contributor.authorDall'Angelo, Sergio
dc.contributor.authorFleming, Ian N.
dc.contributor.authorSchweiger, Lutz F.
dc.contributor.authorZanda, Matteo
dc.contributor.authorO'Hagan, David
dc.date.accessioned2017-07-04T23:33:39Z
dc.date.available2017-07-04T23:33:39Z
dc.date.issued2016-07-25
dc.identifier244261593
dc.identifier86cc3506-1f1a-4684-be5b-c903ca067fac
dc.identifier84978919513
dc.identifier000382885500039
dc.identifier.citationZhang , Q , Dall'Angelo , S , Fleming , I N , Schweiger , L F , Zanda , M & O'Hagan , D 2016 , ' Last-step enzymatic [ 18 F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers ' , Chemistry - A European Journal , vol. 22 , no. 31 , pp. 10998–11004 . https://doi.org/10.1002/chem.201601361en
dc.identifier.issn1521-3765
dc.identifier.otherBibtex: urn:a60426cbb295a36e5f8da8c8cfbdf064
dc.identifier.otherORCID: /0000-0002-0510-5552/work/68281312
dc.identifier.urihttps://hdl.handle.net/10023/11146
dc.descriptionWe thank the Engineering and Physical Sciences Research Council, UK, for a research grant.en
dc.description.abstractWe report a last-step fluorinase-catalyzed [18F]-fluorination of a cysteine-containing RGD peptide. The peptide was attached through sulfur to a modified and more hydrophilic variant of the recently disclosed Barbas linker which was itself linked to a chloroadenosine moiety via a PEGylated chain. The fluorinase was able to use this construct as a substrate for a transhalogenation reaction to generate [18F]-radiolabeled RGD peptides, which retained high affinity to cancer-cell relevant αvβ3 integrins.
dc.format.extent992807
dc.language.isoeng
dc.relation.ispartofChemistry - A European Journalen
dc.subject18F labelingen
dc.subjectBarbas linkeren
dc.subjectBioconjugationen
dc.subjectChemical biologyen
dc.subjectRGD peptideen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQDen
dc.titleLast-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkersen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEPSRCen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1002/chem.201601361
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-07-04
dc.identifier.grantnumberEP/I034734/1en
dc.identifier.grantnumberEP/M01262X/1en


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