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dc.contributor.authorCampbell, C. L.
dc.contributor.authorWood, K.
dc.contributor.authorBrown, C. T. A.
dc.contributor.authorMoseley, H.
dc.identifier.citationCampbell , C L , Wood , K , Brown , C T A & Moseley , H 2016 , ' Monte Carlo modelling of photodynamic therapy treatments comparing clustered three dimensional tumour structures with homogeneous tissue structures ' , Physics in Medicine and Biology , vol. 61 , no. 13 , pp. 4840-4854 .
dc.identifier.otherPURE: 244397692
dc.identifier.otherPURE UUID: f22c7544-98ea-4c7c-a9f4-b66df730e987
dc.identifier.otherBibtex: urn:1fb5fb613fd95b8338d288716ae05ba4
dc.identifier.otherScopus: 84976338367
dc.identifier.otherWOS: 000378094000008
dc.identifier.otherORCID: /0000-0002-4405-6677/work/86537124
dc.descriptionC L Campbell acknowledges financial support from an UK EPSRC PhD studentship (EP/K503162/1) and the Alfred Stewart Trust.en
dc.description.abstractWe explore the effects of three dimensional (3D) tumour structures on depth dependent fluence rates, photodynamic doses (PDD) and fluorescence images through Monte Carlo radiation transfer modelling of photodynamic therapy. The aim with this work was to compare the commonly used uniform tumour densities with non-uniform densities to determine the importance of including 3D models in theoretical investigations. It was found that fractal 3D models resulted in deeper penetration on average of therapeutic radiation and higher PDD. An increase in effective treatment depth of 1 mm was observed for one of the investigated fractal structures, when comparing to the equivalent smooth model. Wide field fluorescence images were simulated, revealing information about the relationship between tumour structure and the appearance of the fluorescence intensity. Our models indicate that the 3D tumour structure strongly affects the spatial distribution of therapeutic light, the PDD and the wide field appearance of surface fluorescence images.
dc.relation.ispartofPhysics in Medicine and Biologyen
dc.rights© 2016, Institute of Physics and Engineering in Medicine. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at /
dc.subjectMonte Carlo modellingen
dc.subjectPhotodynamic therapyen
dc.subjectThree dimensional modellingen
dc.subjectQC Physicsen
dc.subjectR Medicineen
dc.titleMonte Carlo modelling of photodynamic therapy treatments comparing clustered three dimensional tumour structures with homogeneous tissue structuresen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.description.statusPeer revieweden

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