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The trypanosome alternative oxidase : a potential drug target?

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dc.contributor.authorMenzies, Stefanie K.
dc.contributor.authorTulloch, Lindsay B.
dc.contributor.authorFlorence, Gordon J.
dc.contributor.authorSmith, Terry K.
dc.date.accessioned2017-05-29T23:33:54Z
dc.date.available2017-05-29T23:33:54Z
dc.date.issued2018-02
dc.identifier246928770
dc.identifierd385edaa-b1ae-40bb-8351-893c8752e709
dc.identifier000424132700007
dc.identifier84997638231
dc.identifier000424132700007
dc.identifier.citationMenzies , S K , Tulloch , L B , Florence , G J & Smith , T K 2018 , ' The trypanosome alternative oxidase : a potential drug target? ' , Parasitology , vol. 145 , no. 2 , pp. 175-183 . https://doi.org/10.1017/S0031182016002109en
dc.identifier.issn0031-1820
dc.identifier.urihttps://hdl.handle.net/10023/10874
dc.description.abstractNew drugs against Trypanosoma brucei, the causative agent of Human African Trypanosomiasis, are urgently needed to replace the highly toxic and largely ineffective therapies currently used. The trypanosome alternative oxidase (TAO) is an essential and unique mitochondrial protein in these parasites and is absent from mammalian mitochondria, making it an attractive drug target. The structure and function of the protein are now well characterized, with several inhibitors reported in the literature which show potential as clinical drug candidates. In this review we provide an update on the functional activity and structural aspects of TAO. We then discuss TAO inhibitors reported to date, problems encountered with in vivo testing of these compounds, and discuss the future of TAO as a therapeutic target.
dc.format.extent9
dc.format.extent1070209
dc.language.isoeng
dc.relation.ispartofParasitologyen
dc.subjectTrypanosoma alternative oxidaseen
dc.subjectDrug discoveryen
dc.subjectChemotherapyen
dc.subjectHuman African trypanosomiasisen
dc.subjectSleeping sicknessen
dc.subjectTrypanosoma bruceien
dc.subjectQH301 Biologyen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectT-NDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQH301en
dc.subject.lccRMen
dc.titleThe trypanosome alternative oxidase : a potential drug target?en
dc.typeJournal itemen
dc.contributor.sponsorThe Leverhulme Trusten
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doi10.1017/S0031182016002109
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-05-29
dc.identifier.grantnumberRL-2012-025en


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