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Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitions
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dc.contributor.author | Bal, A. M. | |
dc.contributor.author | Coombs, G. W. | |
dc.contributor.author | Holden, M. T. G. | |
dc.contributor.author | Lindsay, J. A. | |
dc.contributor.author | Nimmo, G. R. | |
dc.contributor.author | Tattevin, P. | |
dc.contributor.author | Skov, R. L. | |
dc.date.accessioned | 2017-05-17T23:33:38Z | |
dc.date.available | 2017-05-17T23:33:38Z | |
dc.date.issued | 2016-09 | |
dc.identifier.citation | Bal , A M , Coombs , G W , Holden , M T G , Lindsay , J A , Nimmo , G R , Tattevin , P & Skov , R L 2016 , ' Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitions ' , Journal of Global Antimicrobial Resistance , vol. 6 , pp. 95-101 . https://doi.org/10.1016/j.jgar.2016.04.004 | en |
dc.identifier.issn | 2213-7165 | |
dc.identifier.other | PURE: 242654349 | |
dc.identifier.other | PURE UUID: 4cbbb9c5-e8c5-4b9c-beeb-bcdafdbd02d9 | |
dc.identifier.other | RIS: urn:76FB66AE02F306BEB34160BCB45CC6E4 | |
dc.identifier.other | Scopus: 84971254762 | |
dc.identifier.other | WOS: 000381918100020 | |
dc.identifier.uri | https://hdl.handle.net/10023/10792 | |
dc.description.abstract | The evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, with an increasing recognition of human infection caused by livestock-associated MRSA (LA-MRSA). Genomic studies have enabled us to model the epidemiology of MRSA along these lines. In this review, we discuss the clinical relevance of genomic studies, particularly whole-genome sequencing, in the investigation of outbreaks. We also discuss the blurring of each of the three epidemiological groups (HA-MRSA, CA-MRSA and LA-MRSA), demonstrating the limited relevance of this classification. | |
dc.format.extent | 7 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Global Antimicrobial Resistance | en |
dc.rights | © 2016, International Society for Chemotherapy of Infection and Cancer, published by Elsevier Ltd. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.sciencedirect.com / https://dx.doi.org/10.1016/j.jgar.2016.04.004 | en |
dc.subject | MRSA clones | en |
dc.subject | MRSA epidemiology | en |
dc.subject | Whole-genome sequencing | en |
dc.subject | RA Public aspects of medicine | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RA | en |
dc.title | Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitions | en |
dc.type | Journal item | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Infection Group | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1016/j.jgar.2016.04.004 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2017-05-17 |
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