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Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitions
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dc.contributor.author | Bal, A. M. | |
dc.contributor.author | Coombs, G. W. | |
dc.contributor.author | Holden, M. T. G. | |
dc.contributor.author | Lindsay, J. A. | |
dc.contributor.author | Nimmo, G. R. | |
dc.contributor.author | Tattevin, P. | |
dc.contributor.author | Skov, R. L. | |
dc.date.accessioned | 2017-05-17T23:33:38Z | |
dc.date.available | 2017-05-17T23:33:38Z | |
dc.date.issued | 2016-09 | |
dc.identifier | 242654349 | |
dc.identifier | 4cbbb9c5-e8c5-4b9c-beeb-bcdafdbd02d9 | |
dc.identifier | 84971254762 | |
dc.identifier | 000381918100020 | |
dc.identifier.citation | Bal , A M , Coombs , G W , Holden , M T G , Lindsay , J A , Nimmo , G R , Tattevin , P & Skov , R L 2016 , ' Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitions ' , Journal of Global Antimicrobial Resistance , vol. 6 , pp. 95-101 . https://doi.org/10.1016/j.jgar.2016.04.004 | en |
dc.identifier.issn | 2213-7165 | |
dc.identifier.other | RIS: urn:76FB66AE02F306BEB34160BCB45CC6E4 | |
dc.identifier.uri | https://hdl.handle.net/10023/10792 | |
dc.description.abstract | The evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, with an increasing recognition of human infection caused by livestock-associated MRSA (LA-MRSA). Genomic studies have enabled us to model the epidemiology of MRSA along these lines. In this review, we discuss the clinical relevance of genomic studies, particularly whole-genome sequencing, in the investigation of outbreaks. We also discuss the blurring of each of the three epidemiological groups (HA-MRSA, CA-MRSA and LA-MRSA), demonstrating the limited relevance of this classification. | |
dc.format.extent | 7 | |
dc.format.extent | 133789 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Global Antimicrobial Resistance | en |
dc.subject | MRSA clones | en |
dc.subject | MRSA epidemiology | en |
dc.subject | Whole-genome sequencing | en |
dc.subject | RA Public aspects of medicine | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RA | en |
dc.title | Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitions | en |
dc.type | Journal item | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Infection Group | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1016/j.jgar.2016.04.004 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2017-05-17 |
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