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dc.contributor.authorBal, A. M.
dc.contributor.authorCoombs, G. W.
dc.contributor.authorHolden, M. T. G.
dc.contributor.authorLindsay, J. A.
dc.contributor.authorNimmo, G. R.
dc.contributor.authorTattevin, P.
dc.contributor.authorSkov, R. L.
dc.date.accessioned2017-05-17T23:33:38Z
dc.date.available2017-05-17T23:33:38Z
dc.date.issued2016-09
dc.identifier242654349
dc.identifier4cbbb9c5-e8c5-4b9c-beeb-bcdafdbd02d9
dc.identifier84971254762
dc.identifier000381918100020
dc.identifier.citationBal , A M , Coombs , G W , Holden , M T G , Lindsay , J A , Nimmo , G R , Tattevin , P & Skov , R L 2016 , ' Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitions ' , Journal of Global Antimicrobial Resistance , vol. 6 , pp. 95-101 . https://doi.org/10.1016/j.jgar.2016.04.004en
dc.identifier.issn2213-7165
dc.identifier.otherRIS: urn:76FB66AE02F306BEB34160BCB45CC6E4
dc.identifier.urihttps://hdl.handle.net/10023/10792
dc.description.abstractThe evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, with an increasing recognition of human infection caused by livestock-associated MRSA (LA-MRSA). Genomic studies have enabled us to model the epidemiology of MRSA along these lines. In this review, we discuss the clinical relevance of genomic studies, particularly whole-genome sequencing, in the investigation of outbreaks. We also discuss the blurring of each of the three epidemiological groups (HA-MRSA, CA-MRSA and LA-MRSA), demonstrating the limited relevance of this classification.
dc.format.extent7
dc.format.extent133789
dc.language.isoeng
dc.relation.ispartofJournal of Global Antimicrobial Resistanceen
dc.subjectMRSA clonesen
dc.subjectMRSA epidemiologyen
dc.subjectWhole-genome sequencingen
dc.subjectRA Public aspects of medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRAen
dc.titleGenomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitionsen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection Groupen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1016/j.jgar.2016.04.004
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-05-17


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