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dc.contributor.authorBal, A. M.
dc.contributor.authorCoombs, G. W.
dc.contributor.authorHolden, M. T. G.
dc.contributor.authorLindsay, J. A.
dc.contributor.authorNimmo, G. R.
dc.contributor.authorTattevin, P.
dc.contributor.authorSkov, R. L.
dc.date.accessioned2017-05-17T23:33:38Z
dc.date.available2017-05-17T23:33:38Z
dc.date.issued2016-09
dc.identifier.citationBal , A M , Coombs , G W , Holden , M T G , Lindsay , J A , Nimmo , G R , Tattevin , P & Skov , R L 2016 , ' Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitions ' , Journal of Global Antimicrobial Resistance , vol. 6 , pp. 95-101 . https://doi.org/10.1016/j.jgar.2016.04.004en
dc.identifier.issn2213-7165
dc.identifier.otherPURE: 242654349
dc.identifier.otherPURE UUID: 4cbbb9c5-e8c5-4b9c-beeb-bcdafdbd02d9
dc.identifier.otherRIS: urn:76FB66AE02F306BEB34160BCB45CC6E4
dc.identifier.otherScopus: 84971254762
dc.identifier.otherWOS: 000381918100020
dc.identifier.urihttp://hdl.handle.net/10023/10792
dc.description.abstractThe evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, with an increasing recognition of human infection caused by livestock-associated MRSA (LA-MRSA). Genomic studies have enabled us to model the epidemiology of MRSA along these lines. In this review, we discuss the clinical relevance of genomic studies, particularly whole-genome sequencing, in the investigation of outbreaks. We also discuss the blurring of each of the three epidemiological groups (HA-MRSA, CA-MRSA and LA-MRSA), demonstrating the limited relevance of this classification.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofJournal of Global Antimicrobial Resistanceen
dc.rights© 2016, International Society for Chemotherapy of Infection and Cancer, published by Elsevier Ltd. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.sciencedirect.com / https://dx.doi.org/10.1016/j.jgar.2016.04.004en
dc.subjectMRSA clonesen
dc.subjectMRSA epidemiologyen
dc.subjectWhole-genome sequencingen
dc.subjectRA Public aspects of medicineen
dc.subject.lccRAen
dc.titleGenomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus : blurring of the traditional definitionsen
dc.typeJournal itemen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Infection Groupen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1016/j.jgar.2016.04.004
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-05-17


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