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dc.contributor.authorYang, Yuan
dc.contributor.authorWen, Yunhong
dc.contributor.authorBedi, Carolyn
dc.contributor.authorHumphris, Gerry
dc.identifier.citationYang , Y , Wen , Y , Bedi , C & Humphris , G 2017 , ' The relationship between cancer patient's fear of recurrence and chemotherapy : a systematic review and meta-analysis ' , Journal of Psychosomatic Research , vol. 98 , pp. 55-63 .
dc.identifier.otherPURE: 249930915
dc.identifier.otherPURE UUID: 7bd9d975-517e-4e0e-bf10-79e5273201bf
dc.identifier.otherRIS: urn:ADC6E3C3C30AADA786078C7A948F6E85
dc.identifier.otherScopus: 85018881729
dc.identifier.otherWOS: 000403735100008
dc.descriptionThis review was funded by Breast Cancer Now (grant number 6873).en
dc.description.abstractObjective:   The study aim was to provide an overview of the current evidence available on the link between chemotherapy (CTX) and fear of cancer recurrence (FoR). Methods:   PubMED, Medline, Embase, PsycINFO and Web of Science databases were searched to identify relevant studies. Two authors independently selected and assessed the studies regarding eligibility criteria. Meta-analysis of suitable studies was conducted, and quality rated. Results:   Forty eligible studies were included in the systematic review and twenty-nine of them were included in further meta-analysis. Meta-analysis of the available data confirmed a weak relationship between CTX and FoR (29 studies, 30,176 patients, overall r = 0.093, 95%, CI: 0.062–0.123, P < 0.001). Conclusions:   The meta-analysis demonstrates a weak but significant relationship between cancer patient's FoR and the receipt of chemotherapy. However, these results should be interpreted with caution. Further investigation is warranted to explore possible mechanisms of FoR increase in patients who receive chemotherapy. Longitudinal studies assessing the trajectory of FoR during chemotherapy are also warranted.
dc.relation.ispartofJournal of Psychosomatic Researchen
dc.rights© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (
dc.subjectFear of recurrenceen
dc.subjectSystematic reviewen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectBF Psychologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleThe relationship between cancer patient's fear of recurrence and chemotherapy : a systematic review and meta-analysisen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. WHO Collaborating Centre for International Child & Adolescent Health Policyen
dc.contributor.institutionUniversity of St Andrews. Health Psychologyen
dc.contributor.institutionUniversity of St Andrews. St Andrews Sustainability Instituteen
dc.description.statusPeer revieweden

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