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dc.contributor.authorKuruvilla, Maneesh
dc.contributor.authorAinge, James Alexander
dc.date.accessioned2017-05-17T10:30:15Z
dc.date.available2017-05-17T10:30:15Z
dc.date.issued2017-05-17
dc.identifier.citationKuruvilla , M & Ainge , J A 2017 , ' Lateral entorhinal cortex lesions impair local spatial frameworks ' Frontiers in Systems Neuroscience , vol. 11 , 30 . DOI: 10.3389/fnsys.2017.00030en
dc.identifier.issn1662-5137
dc.identifier.otherPURE: 249879789
dc.identifier.otherPURE UUID: fa48ff41-72e6-4b6b-ad63-d691c6db263c
dc.identifier.otherScopus: 85021381210
dc.identifier.urihttp://hdl.handle.net/10023/10790
dc.identifier.urihttp://journal.frontiersin.org/file/downloadfile/264055_supplementary-materials_tables_1_docx/octet-stream/Table%201.DOCX/1/264055en
dc.description.abstractA prominent theory in the neurobiology of memory processing is that episodic memory is supported by contextually gated spatial representations in the hippocampus formed by combining spatial information from medial entorhinal cortex (MEC) with non-spatial information from lateral entorhinal cortex (LEC). However, there is a growing body of evidence from lesion and single-unit recording studies in rodents suggesting that LEC might have a role in encoding space, particularly the current and previous locations of objects within the local environment. Landmarks, both local and global, have been shown to control the spatial representations hypothesised to underlie cognitive maps. Consequently, it has recently been suggested that information processing within this network might be organized with reference to spatial scale with LEC and MEC providing information about local and global spatial frameworks respectively. In the present study, we trained animals to search for food using either a local or global spatial framework. Animals were re-tested on both tasks after receiving excitotoxic lesions of either the MEC or LEC. LEC lesioned animals were impaired in their ability to learn a local spatial framework task. LEC lesioned animals were also impaired on an object recognition task involving multiple local features but unimpaired at recognizing a single familiar object. Together, this suggests that LEC is involved in associating features of the local environment. However, neither LEC nor MEC lesions impaired performance on the global spatial framework task.en
dc.format.extent12en
dc.language.isoeng
dc.relation.ispartofFrontiers in Systems Neuroscienceen
dc.rightsCopyright © 2017 Kuruvilla and Ainge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectHippocampusen
dc.subjectSpatial memoryen
dc.subjectNavigationen
dc.subjectMedial entorhinal cortexen
dc.subjectObject recognitionen
dc.subjectAllocentricen
dc.subjectQA Mathematicsen
dc.subjectQH301 Biologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccQAen
dc.subject.lccQH301en
dc.subject.lccRC0321en
dc.titleLateral entorhinal cortex lesions impair local spatial frameworksen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.3389/fnsys.2017.00030
dc.description.statusPeer revieweden


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