A synthetic replicator drives a propagating reaction-diffusion front
Abstract
A simple synthetic autocatalytic replicator is capable of establishing and driving the propagation of a reaction-diffusion front within a 50 µL syringe. This replicator templates its own synthesis through a 1,3-dipolar cycloaddition reaction between a nitrone component, equipped with a 9-ethynylanthracene optical tag, and a maleimide. Kinetic studies using NMR and UV-Vis spectroscopies confirm that the replicator forms ef-ficiently and with high diastereoselectivity and this rep-lication process brings about a dramatic change in opti-cal properties of the sample – a change in the color of the fluorescence in the sample from yellow to blue. The addition of a small amount of the pre-formed replicator at a specific location within a microsyringe, filled with the reaction building blocks, results in the initiation and propagation of a reaction-diffusion front. The realization of a replicator capable of initiating a reaction-diffusion front provides a platform for the examination of inter-connected replicating networks under non-equilibrium conditions involving diffusion processes.
Citation
Bottero , I , Huck , J , Kosikova , T & Philp , D 2016 , ' A synthetic replicator drives a propagating reaction-diffusion front ' , Journal of the American Chemical Society , vol. 138 , no. 21 , pp. 6723-6726 . https://doi.org/10.1021/jacs.6b03372
Publication
Journal of the American Chemical Society
Status
Peer reviewed
ISSN
0002-7863Type
Journal article
Description
The authors thank EPSRC for postgraduate studentship awards to JH (EP/ E017851/1) and TK (EP/K503162/1).Collections
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