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dc.contributor.authorGadoev, Jamshid
dc.contributor.authorAsadov, Damin
dc.contributor.authorHarries, Anthony D.
dc.contributor.authorParpieva, Nargiza
dc.contributor.authorTayler-Smith, Katie
dc.contributor.authorIsaakidis, Petros
dc.contributor.authorAli, Engy
dc.contributor.authorHinderaker, Sven Gudmund
dc.contributor.authorOgtay, Gozalov
dc.contributor.authorRamsay, Andrew
dc.contributor.authorJalolov, Avazbek
dc.contributor.authorDara, Masoud
dc.date.accessioned2017-05-08T11:30:10Z
dc.date.available2017-05-08T11:30:10Z
dc.date.issued2017-05-04
dc.identifier.citationGadoev , J , Asadov , D , Harries , A D , Parpieva , N , Tayler-Smith , K , Isaakidis , P , Ali , E , Hinderaker , S G , Ogtay , G , Ramsay , A , Jalolov , A & Dara , M 2017 , ' Recurrent tuberculosis and associated factors : a five-year countrywide study in Uzbekistan ' , PLoS One , vol. 12 , no. 5 , e0176473 . https://doi.org/10.1371/journal.pone.0176473en
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 249950794
dc.identifier.otherPURE UUID: aa871ce6-9b05-483e-974e-755f1fc3b52d
dc.identifier.otherRIS: urn:B0EF4B048EE13F96CAF469A4B4F13BFB
dc.identifier.otherScopus: 85018306841
dc.identifier.otherWOS: 000400648500048
dc.identifier.urihttp://hdl.handle.net/10023/10721
dc.description.abstractBackground:  In Uzbekistan, despite stable and relatively high tuberculosis treatment success rates, relatively high rates of recurrent tuberculosis have recently been reported. Recurrent tuberculosis is when a patient who was treated for pulmonary tuberculosis and cured, later develops the disease again. This requires closer analysis to identify possible causes and recommend interventions to improve the situation. Using countrywide data, this study aimed to analyse trends in recurrent tuberculosis cases and describe their associations with socio-demographic and clinical factors. Method:  Countrywide retrospective cohort study comparing recurrent tuberculosis patients with all new tuberculosis patients registered within the NTP between January 2006 and December 2010 using routinely collected data. Determinants studied were baseline characteristics and treatment outcomes. Results:  Of 107,380 registered patients during the period January 2006 and December 2010, 9358 (8.7%) were recurrent cases. Between 2006 and 2008, the number of recurrent cases per annum increased from 1530 to 2081, then fell slightly thereafter from 2081 to 1888 cases. The proportion of all notified cases during this period increased from 6.5% to 9.9%. Factors associated with recurrent tuberculosis included age (35–55 years old), having smear positive pulmonary tuberculosis, residing in certain areas of Uzbekistan, having particular co-morbidities (including chronic obstructive pulmonary disease and HIV), and being unemployed, a pensioner or disabled. Recurrent tuberculosis patients also had a higher likelihood of having an unfavourable treatment outcome. Conclusion:  Despite signs of declining national tuberculosis notifications between 2006 and 2010, the relative proportion of recurrent cases appears to have increased. These findings, together with the identification of possible risk factors associated with recurrent tuberculosis, highlight various areas where Uzbekistan needs to focus its tuberculosis control efforts, particularly in light of the country’s rapidly emerging multi drug resistant tuberculosis epidemic.
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofPLoS Oneen
dc.rights© 2017 Gadoev et al. In accordance with WHO’s open-access publication policy for all work funded by WHO or authored/co-authored by WHO staff members, the WHO retains the copyright of this publication through a Creative Commons Attribution IGO license (http://creativecommons.org/licenses/by/3.0/igo/legalcode) which permits unrestricted use, distribution and reproduction in any medium provided the original work is properly cited.en
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectDASen
dc.subject.lccRA0421en
dc.titleRecurrent tuberculosis and associated factors : a five-year countrywide study in Uzbekistanen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0176473
dc.description.statusPeer revieweden
dc.identifier.urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176473#sec019en


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