A valuable upgrade to the portfolio of cycloaddition reactions
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Recently Antonchick and Manna described a unique annulation that knits together three acetophenones to construct cyclopropanes. The cascade is mediated by organo-copper and free radical species and amounts to the first known [1+1+1] cyclotrimerization. It works well for ketones having electron-deficient or electron-rich substituents in their aryl rings.
Walton , J C 2016 , ' A valuable upgrade to the portfolio of cycloaddition reactions ' Angewandte Chemie International Edition , vol 55 , no. 25 , pp. 7034-7036 . DOI: 10.1002/anie.201602891
Angewandte Chemie International Edition
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1002/anie.201602891
DescriptionThe author thanks EaStCHEM for financial support.
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