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dc.contributor.authorLythgoe, Katrina A.
dc.contributor.authorGardner, Andy
dc.contributor.authorPybus, Oliver G.
dc.contributor.authorGrove, Joe
dc.date.accessioned2017-04-18T09:30:12Z
dc.date.available2017-04-18T09:30:12Z
dc.date.issued2017-05
dc.identifier.citationLythgoe , K A , Gardner , A , Pybus , O G & Grove , J 2017 , ' Short-sighted virus evolution and a germline hypothesis for chronic viral infections ' , Trends in Microbiology , vol. 25 , no. 5 , pp. 336-348 . https://doi.org/10.1016/j.tim.2017.03.003en
dc.identifier.issn0966-842X
dc.identifier.otherPURE: 249337925
dc.identifier.otherPURE UUID: 67530cef-229a-4a8d-8037-49f83888ec4e
dc.identifier.otherScopus: 85016488461
dc.identifier.otherWOS: 000399286000005
dc.identifier.urihttps://hdl.handle.net/10023/10626
dc.descriptionThis work was funded by The Wellcome Trust and The Royal Society grant numbers wtvm055984 (KAL) and 107653/Z/15/Z (JG), The Natural Environment Research Council grant number NE/K009524/1 (AG), and The European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC grant number 614725-PATHPHYLODYN (OGP).en
dc.description.abstractWith extremely short generation times and high mutability, many viruses can rapidly evolve and adapt to changing environments. This ability is generally beneficial to viruses as it allows them to evade host immune responses, evolve new behaviours, and exploit ecological niches. However, natural selection typically generates adaptation in response to the immediate selection pressures that a virus experiences in its current host. Consequently, we argue that some viruses, particularly those characterised by long durations of infection and ongoing replication, may be susceptible to short-sighted evolution, whereby a virus’ adaptation to its current host will be detrimental to its onward transmission within the host population. Here we outline the concept of short-sighted viral evolution and provide examples of how it may negatively impact viral transmission among hosts. We also propose that viruses that are vulnerable to short-sighted evolution may exhibit strategies that minimise its effects. We speculate on the various mechanisms by which this may be achieved, including viral life history strategies that result in low rates of within-host evolution, or the establishment of a ‘germline’ lineage of viruses that avoids short-sighted evolution. These concepts provide a new perspective on the way in which some viruses have been able to establish and maintain global pandemics.
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofTrends in Microbiologyen
dc.rights© 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectVirusen
dc.subjectEvolutionen
dc.subjectTransmissionen
dc.subjectQH301 Biologyen
dc.subjectQR Microbiologyen
dc.subjectQR180 Immunologyen
dc.subjectT-NDASen
dc.subject.lccQH301en
dc.subject.lccQRen
dc.subject.lccQR180en
dc.titleShort-sighted virus evolution and a germline hypothesis for chronic viral infectionsen
dc.typeJournal articleen
dc.contributor.sponsorNERCen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biological Diversityen
dc.identifier.doihttps://doi.org/10.1016/j.tim.2017.03.003
dc.description.statusPeer revieweden
dc.identifier.grantnumberNE/K009524/1en


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