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dc.contributor.authorZimmer, Cédric
dc.contributor.authorLarriva Hormigos, Maria
dc.contributor.authorBoogert, Neeltje J
dc.contributor.authorSpencer, Karen A
dc.identifier.citationZimmer , C , Larriva Hormigos , M , Boogert , N J & Spencer , K A 2017 , ' Transgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quail ' Scientific Reports , vol. 7 , 46125 .
dc.identifier.otherPURE: 249375919
dc.identifier.otherPURE UUID: e6d00afd-fc27-41d1-a608-775796b2c8fe
dc.identifier.otherPubMed: 28387355
dc.identifier.otherPubMed: 28387355
dc.identifier.otherPubMedCentral: PMC5384203
dc.identifier.otherScopus: 85017231498
dc.identifier.otherWOS: 000398564600001
dc.descriptionThis study was funded by a BBSRC David Phillips Research Fellowship to K.A. Spencer (BB/L002264/1)en
dc.description.abstractAn interesting aspect of developmental programming is the existence of transgenerational effects that influence offspring characteristics and performance later in life. These transgenerational effects have been hypothesized to allow individuals to cope better with predictable environmental fluctuations and thus facilitate adaptation to changing environments. Here, we test for the first time how early-life stress drives developmental programming and transgenerational effects of maternal exposure to early-life stress on several phenotypic traits in their offspring in a functionally relevant context using a fully factorial design. We manipulated pre- and/or post-natal stress in both Japanese quail mothers and offspring and examined the consequences for several stress-related traits in the offspring generation. We show that pre-natal stress experienced by the mother did not simply affect offspring phenotype but resulted in the inheritance of the same stress-coping traits in the offspring across all phenotypic levels that we investigated, shaping neuroendocrine, physiological and behavioural traits. This may serve mothers to better prepare their offspring to cope with later environments where the same stressors are experienced.
dc.relation.ispartofScientific Reportsen
dc.rights© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
dc.subjectBF Psychologyen
dc.titleTransgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quailen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.description.statusPeer revieweden

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