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dc.contributor.authorAnastasiou, A. D.
dc.contributor.authorThomson, Caroline Louise
dc.contributor.authorHussain, Syed Asad
dc.contributor.authorEdwards, Tom J.
dc.contributor.authorStrafford, S.
dc.contributor.authorMalinowski, M.
dc.contributor.authorMathieson, R.
dc.contributor.authorBrown, C. Tom A.
dc.contributor.authorBrown, A. P.
dc.contributor.authorDuggal, M. S.
dc.contributor.authorJha, A.
dc.date.accessioned2017-04-06T23:33:21Z
dc.date.available2017-04-06T23:33:21Z
dc.date.issued2016-07-05
dc.identifier.citationAnastasiou , A D , Thomson , C L , Hussain , S A , Edwards , T J , Strafford , S , Malinowski , M , Mathieson , R , Brown , C T A , Brown , A P , Duggal , M S & Jha , A 2016 , ' Sintering of calcium phosphates with a femtosecond pulsed laser for hard tissue engineering ' , Materials & Design , vol. 101 , pp. 346-354 . https://doi.org/10.1016/j.matdes.2016.03.159en
dc.identifier.issn0264-1275
dc.identifier.otherPURE: 241802207
dc.identifier.otherPURE UUID: 59170fdd-ffa3-40cd-ab8d-d8e4497c6a7c
dc.identifier.otherRIS: urn:6665A04C75DE92C906D214A2022A160F
dc.identifier.otherScopus: 84963604683
dc.identifier.otherWOS: 000375413100044
dc.identifier.otherORCID: /0000-0002-4405-6677/work/86537112
dc.identifier.urihttps://hdl.handle.net/10023/10594
dc.descriptionThe authors acknowledge support from the sponsors of this work; the EPSRC LUMIN (EP/K020234/1) and EU-Marie-Curie-IAPP LUSTRE (324538) projects.en
dc.description.abstractDirect laser sintering on hard tissues is likely to open new pathways for personalised medicine. To minimise irradiation damage of the surrounding soft tissues, lasers operating at wavelengths that are ‘safe’ for the tissues and biomaterials with improved optical properties are required. In this work laser sintering is demonstrated with the use of an ultrafast, femtosecond (100 fs) pulsed laser operating at a wavelength of 1045 nm and two existing calcium phosphate minerals (brushite and hydroxyapatite) which have been improved after doping with iron (10 mol%). Femtosecond laser irradiation caused transformation of the Fe3+-doped brushite and Fe3+-doped HAp samples into β-calcium pyrophosphate and calcium-iron-phosphate, respectively, with simultaneous evidence for microstructural sintering and densification. After estimating the temperature profile at the surface of the samples we suggest that soft tissues over 500 μm from the irradiated zone would be safe from thermal damage. This novel laser processing provides a means to control the phase constitution and the morphology of the finished surfaces. The porous structure of β-pyrophosphate might be suitable for applications in bone regeneration by supporting osteogenic cell activity while, the densified Fe3+-rich calcium-iron-phosphate may be promising for applications like dental enamel restoration.
dc.language.isoeng
dc.relation.ispartofMaterials & Designen
dc.rights© 2016, Publisher / the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.sciencedirect.com / https://dx.doi.org/10.1016/j.matdes.2016.03.159en
dc.subjectSelective Laser Sinteringen
dc.subjectFemtosecond lasersen
dc.subjectHeat dissipationen
dc.subjectPhase transformationsen
dc.subjectCalcium phosphatesen
dc.subjectQC Physicsen
dc.subjectDASen
dc.subjectBDCen
dc.subject.lccQCen
dc.titleSintering of calcium phosphates with a femtosecond pulsed laser for hard tissue engineeringen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorEuropean Commissionen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.identifier.doihttps://doi.org/10.1016/j.matdes.2016.03.159
dc.description.statusPeer revieweden
dc.date.embargoedUntil2017-04-06
dc.identifier.grantnumberen
dc.identifier.grantnumber324538en


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