6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis

N P, Rifahath Mon; Cordes, David Bradford; Slawin, Alexandra Martha Zoya; Smith, Andrew David

Show simple item record

Files in this item

Name:: Smith_2017_CC_6_exo_CCBYVoR.pdf
Size:: 2.951Mb
Format:: PDF

View/Open

Item metadata

dc.contributor.author	N P, Rifahath Mon
dc.contributor.author	Cordes, David Bradford
dc.contributor.author	Slawin, Alexandra Martha Zoya
dc.contributor.author	Smith, Andrew David
dc.date.accessioned	2017-02-24T09:30:10Z
dc.date.available	2017-02-24T09:30:10Z
dc.date.issued	2017-02-28
dc.identifier.citation	N P , R M , Cordes , D B , Slawin , A M Z & Smith , A D 2017 , ' 6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis ' , Chemical Communications , vol. 53 , no. 17 , pp. 2555-2558 . https://doi.org/10.1039/C6CC10178J	en
dc.identifier.issn	1359-7345
dc.identifier.other	PURE: 248996963
dc.identifier.other	PURE UUID: 7e332261-8787-4384-9d07-0cf857a59ab2
dc.identifier.other	Scopus: 85013929588
dc.identifier.other	ORCID: /0000-0002-2104-7313/work/36567478
dc.identifier.other	ORCID: /0000-0002-5366-9168/work/29985366
dc.identifier.other	ORCID: /0000-0002-9527-6418/work/56861410
dc.identifier.other	WOS: 000395873100005
dc.identifier.uri	https://hdl.handle.net/10023/10358
dc.description	The authors thank the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT, grant code EP/L016419/1, RMNP) for funding.The European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement No. 279850 is also acknowledged. ADS thanks the Royal Society for a Wolfson Research Merit Award	en
dc.description.abstract	The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup proved necessary to minimize product epimerization and maximize product er, providing cis-chromenones in excellent yield, and with excellent diastereo- and enantioselectivity.
dc.language.iso	eng
dc.relation.ispartof	Chemical Communications	en
dc.rights	Copyright 2017 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.	en
dc.subject	QD Chemistry	en
dc.subject	TP Chemical technology	en
dc.subject	NDAS	en
dc.subject.lcc	QD	en
dc.subject.lcc	TP	en
dc.title	6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis	en
dc.type	Journal article	en
dc.contributor.sponsor	EPSRC	en
dc.contributor.sponsor	European Commission	en
dc.description.version	Publisher PDF	en
dc.contributor.institution	University of St Andrews. School of Chemistry	en
dc.contributor.institution	University of St Andrews. EaSTCHEM	en
dc.contributor.institution	University of St Andrews. Biomedical Sciences Research Complex	en
dc.identifier.doi	https://doi.org/10.1039/C6CC10178J
dc.description.status	Peer reviewed	en
dc.identifier.grantnumber	EP/L016419/1	en
dc.identifier.grantnumber	N/A	en

This item appears in the following Collection(s)

University of St Andrews Research

Show simple item record