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dc.contributor.authorN P, Rifahath Mon
dc.contributor.authorCordes, David Bradford
dc.contributor.authorSlawin, Alexandra Martha Zoya
dc.contributor.authorSmith, Andrew David
dc.date.accessioned2017-02-24T09:30:10Z
dc.date.available2017-02-24T09:30:10Z
dc.date.issued2017-02-28
dc.identifier.citationN P , R M , Cordes , D B , Slawin , A M Z & Smith , A D 2017 , ' 6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis ' Chemical Communications , vol. 53 , no. 17 , pp. 2555-2558 . https://doi.org/10.1039/C6CC10178Jen
dc.identifier.issn1359-7345
dc.identifier.otherPURE: 248996963
dc.identifier.otherPURE UUID: 7e332261-8787-4384-9d07-0cf857a59ab2
dc.identifier.otherScopus: 85013929588
dc.identifier.otherORCID: /0000-0002-2104-7313/work/36567478
dc.identifier.otherORCID: /0000-0002-5366-9168/work/29985366
dc.identifier.otherORCID: /0000-0002-9527-6418/work/56861410
dc.identifier.otherWOS: 000395873100005
dc.identifier.urihttp://hdl.handle.net/10023/10358
dc.descriptionThe authors thank the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT, grant code EP/L016419/1, RMNP) for funding.The European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement No. 279850 is also acknowledged. ADS thanks the Royal Society for a Wolfson Research Merit Awarden
dc.description.abstractThe catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup proved necessary to minimize product epimerization and maximize product er, providing cis-chromenones in excellent yield, and with excellent diastereo- and enantioselectivity.
dc.language.isoeng
dc.relation.ispartofChemical Communicationsen
dc.rightsCopyright 2017 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en
dc.subjectQD Chemistryen
dc.subjectTP Chemical technologyen
dc.subjectNDASen
dc.subject.lccQDen
dc.subject.lccTPen
dc.title6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesisen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1039/C6CC10178J
dc.description.statusPeer revieweden


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