St Andrews Research Repository

St Andrews University Home
View Item 
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  •   St Andrews Research Repository
  • University of St Andrews Research
  • University of St Andrews Research
  • University of St Andrews Research
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Effects of lesions of the subthalamic nucleus/zona incerta area and dorsomedial striatum on attentional set-shifting in the rat

Thumbnail
View/Open
Tait_2017_Neuroscience_AttentionalSet_shifting_CC.pdf (790.8Kb)
Date
14/03/2017
Author
Tait, David S.
Phillips, Janice M.
Blackwell, Andrew D.
Brown, Verity J.
Keywords
Basal ganglia
Parkinson's disease
Dopamine
Subthalmic nucleus
Attentional set-shifting
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
NDAS
Metadata
Show full item record
Altmetrics Handle Statistics
Altmetrics DOI Statistics
Abstract
Patients with Parkinson’s disease show cognitive impairments, including difficulty in shifting attention between perceptual dimensions of complex stimuli. Inactivation of the subthalamic nucleus (STN) has been shown to be effective in ameliorating the motor abnormalities associated with striatal dopamine depletion, but it is possible that STN inactivation might result in additional, perhaps attentional, deficits. This study examined the effects of: dopamine depletion from the dorsomedial striatum (DMS); lesions of the STN area; and the effects of the two lesions together, on the ability to shift attentional set in the rat. In a single session, rats performed the intradimensional/extradimensional (ID/ED) test of attentional set-shifting. This comprises a series of seven, two-choice discriminations, including acquisitions of novel discriminations in which the relevant stimulus is either in the currently-attended dimension (ID) or the currently-unattended dimension (ED shift) and reversals following each acquisition stage. Bilateral lesions were made by injection of 6-hydroxydopamine into the DMS, resulting in a selective impairment in reversal learning. Large bilateral ibotenic acid lesions centred on the STN resulted in an increase in trials to criterion in the initial stages, but learning rate improved within the session. There was no evidence of a ‘cost’ of set-shifting – the ED stage was completed in fewer trials than the ID stage – and neither was there a cost of reversal learning. Strikingly, combined lesions of both regions did not resemble the effects of either lesion alone and resulted in no apparent deficits.
Citation
Tait , D S , Phillips , J M , Blackwell , A D & Brown , V J 2017 , ' Effects of lesions of the subthalamic nucleus/zona incerta area and dorsomedial striatum on attentional set-shifting in the rat ' , Neuroscience , vol. 345 , pp. 287-296 . https://doi.org/10.1016/j.neuroscience.2016.08.008
Publication
Neuroscience
Status
Peer reviewed
DOI
https://doi.org/10.1016/j.neuroscience.2016.08.008
ISSN
0306-4522
Type
Journal article
Rights
© 2016 The Authors. Published by Elsevier Ltd on behalf of IBRO. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Description
This work was supported by The Wellcome Trust (project Grant 051945/z/97). Andrew Blackwell was in receipt of a BBSRC Studentship.
Collections
  • University of St Andrews Research
URL
http://europepmc.org/articles/PMC5321403
URI
http://hdl.handle.net/10023/10301

Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Advanced Search

Browse

All of RepositoryCommunities & CollectionsBy Issue DateNamesTitlesSubjectsClassificationTypeFunderThis CollectionBy Issue DateNamesTitlesSubjectsClassificationTypeFunder

My Account

Login

Open Access

To find out how you can benefit from open access to research, see our library web pages and Open Access blog. For open access help contact: openaccess@st-andrews.ac.uk.

Accessibility

Read our Accessibility statement.

How to submit research papers

The full text of research papers can be submitted to the repository via Pure, the University's research information system. For help see our guide: How to deposit in Pure.

Electronic thesis deposit

Help with deposit.

Repository help

For repository help contact: Digital-Repository@st-andrews.ac.uk.

Give Feedback

Cookie policy

This site may use cookies. Please see Terms and Conditions.

Usage statistics

COUNTER-compliant statistics on downloads from the repository are available from the IRUS-UK Service. Contact us for information.

© University of St Andrews Library

University of St Andrews is a charity registered in Scotland, No SC013532.

  • Facebook
  • Twitter