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dc.contributor.authorJavanbakht, Mehdi
dc.contributor.authorAzuara-Blanco, Augusto
dc.contributor.authorBurr, Jennifer Margaret
dc.contributor.authorRamsay, Craig
dc.contributor.authorCooper, David
dc.contributor.authorCochrane, Claire
dc.contributor.authorNorrie, John
dc.contributor.authorScotland, Graham
dc.date.accessioned2017-01-13T12:30:12Z
dc.date.available2017-01-13T12:30:12Z
dc.date.issued2017-01
dc.identifier.citationJavanbakht , M , Azuara-Blanco , A , Burr , J M , Ramsay , C , Cooper , D , Cochrane , C , Norrie , J & Scotland , G 2017 , ' Early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma : an economic evaluation based on data from the EAGLE trial ' , BMJ Open , vol. 7 , no. 1 , e013254 . https://doi.org/10.1136/bmjopen-2016-013254en
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 248137930
dc.identifier.otherPURE UUID: 0a9d403e-bbae-4c1b-91b9-d54a3711551a
dc.identifier.otherScopus: 85009761421
dc.identifier.otherORCID: /0000-0002-9478-738X/work/60196213
dc.identifier.otherWOS: 000395590300087
dc.identifier.urihttp://hdl.handle.net/10023/10094
dc.descriptionThis study was funded by the UK Medical Research Council (ref G0701604), and managed by the National Institute for Health Research (NIHR-EME 09-800-26) on behalf of the MRC-NIHR partnership, Efficiency and Mechanism Evaluation Programme. The Health Services Research Unit and the Health Economics Research Unit are both funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates.en
dc.description.abstractObjective To investigate the cost effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma (PACG) compared to standard care. Design Cost effectiveness analysis alongside a multicentre pragmatic two-arm randomised controlled trial. Patients were followed up for 36 months and data on health service utilisation and health state utility were collected and analysed within the trial time horizon. A Markov model was developed to extrapolate the results over a 5 and 10-year time horizon. Setting: 22 hospital eye services in the United Kingdom. Population: Males and females aged 50 years or over with newly diagnosed PACG or primary angle closure (PAC). Interventions: Lens extraction compared to standard care (i.e. laser iridotomy followed by medical therapy and glaucoma surgery). Outcome measures: Costs of primary and secondary health care utilisation (UK NHS perspective), quality adjusted life years (QALYs) and the incremental cost effectiveness ratio (ICER) for lens extraction versus standard care. Results: The mean age of participants was 67.5 (8.42), 57.5% were female, 44.6% had both eyes eligible, 1.4% were of Asian ethnicity and 35.4% had PAC. Mean health service costs were higher in patients randomized to lens extraction: £2,467 versus £1,486. Mean adjusted QALYs were also higher with early lens extraction: 2.602 versus 2.533. The ICER for lens extraction versus standard care was £14,284 per QALY gained at three years. Modelling suggests that the ICER may drop to £7,090 per QALY gained by 5 years, and that lens extraction may be cost saving by 10 years. Our results are generally robust to changes in the key input parameters and assumptions. Conclusions We find that lens extraction has a 67-89% chance of being cost effective at 3 years, and that it may be cost saving by 10 years.
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofBMJ Openen
dc.rightsCopyright the Authors, 2017. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/en
dc.subjectCost-effectivenessen
dc.subjectLens extractionen
dc.subjectLaser peripheral iridotomyen
dc.subjectRandomised controlled trialen
dc.subjectAngle closure glaucomaen
dc.subjectQALYen
dc.subjectRD Surgeryen
dc.subjectRE Ophthalmologyen
dc.subjectNDASen
dc.subject.lccRDen
dc.subject.lccREen
dc.titleEarly lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma : an economic evaluation based on data from the EAGLE trialen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2016-013254
dc.description.statusPeer revieweden
dc.identifier.urlhttp://bmjopen.bmj.com/content/7/1/e013254en


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